LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter

Si-Li He; Ya-Ling Chen; Qi-Hua Chen; Qi Tian; Shui-Jing Yi

doi:10.1186/s10020-022-00521-5

Molecular Medicine (Sep 2022)

LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter

Si-Li He,
Ya-Ling Chen,
Qi-Hua Chen,
Qi Tian,
Shui-Jing Yi

Affiliations

Si-Li He: Department of Gynaecology, The Third Xiangya Hospital of Central South University
Ya-Ling Chen: Hunan University of Chinese Medicine
Qi-Hua Chen: Surgical Department, The First Hospital of Hunan University of Chinese Medicine
Qi Tian: Department of Medical Genetics, Maternal and Child Health Hospital of Hunan Province
Shui-Jing Yi: Department of Gynaecology, The Third Xiangya Hospital of Central South University

DOI: https://doi.org/10.1186/s10020-022-00521-5
Journal volume & issue: Vol. 28, no. 1
pp. 1 – 12

Abstract

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Highlights 1. LncRNA KCNQ1OT1 is upregulated, while EIF2B5 is downregulated in OC tissues and cells. 2. Knockdown of KCNQ1OT1 represses OC cell proliferation and metastasis. 3. KCNQ1OT1 decreases EIF2B5 expression by recruiting DNA methyltransferases into EIF2B5 promoter, thereby promoting OC progression.

Published in Molecular Medicine

ISSN: 1076-1551 (Print); 1528-3658 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Therapeutics. Pharmacology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://molmed.biomedcentral.com

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Abstract

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