Российский кардиологический журнал (Sep 2022)

Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry "Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors"

  • G. P. Arutyunov,
  • E. I. Tarlovskaya,
  • A. G. Arutyunov,
  • Yu. N. Belenkov,
  • A. O. Konradi,
  • Yu. M. Lopatin,
  • A. P. Rebrov,
  • S. N. Tereshchenko,
  • A. I. Chesnikova,
  • G. G. Airapetyan,
  • A. P. Babin,
  • I. G. Bakulin,
  • N. V. Bakulina,
  • L. A. Balykova,
  • A. S. Blagonravova,
  • M. V. Boldina,
  • M. I. Butomo,
  • A. R. Vaisberg,
  • A. S. Galyavich,
  • V. V. Gomonova,
  • N. Yu. Grigorieva,
  • I. V. Gubareva,
  • I. V. Demko,
  • A. V. Evzerikhina,
  • A. V. Zharkov,
  • A. A. Zateyshchikova,
  • U. K. Kamilova,
  • Z. F. Kim,
  • T. Yu. Kuznetsova,
  • A. N. Kulikov,
  • N. V. Lareva,
  • E. V. Makarova,
  • S. V. Malchikova,
  • S. V. Nedogoda,
  • M. M. Petrova,
  • I. G. Pochinka,
  • K. V. Protasov,
  • D. N. Protsenko,
  • D. Yu. Ruzanov,
  • S. A. Saiganov,
  • A. Sh. Sarybaev,
  • N. M. Selezneva,
  • A. B. Sugraliev,
  • I. V. Fomin,
  • O. V. Khlynova,
  • O. Yu. Chizhova,
  • I. I. Shaposhnik,
  • D. A. Schukarev,
  • A. K. Abdrakhmanova,
  • S. A. Avetisyan,
  • O. G. Avoyan,
  • K. K. Azaryan,
  • G. T. Aimakhanova,
  • D. A. Aiypova,
  • A. Ch. Akunov,
  • M. K. Alieva,
  • A. R. Almukhambedova,
  • A. V. Aparkina,
  • O. R. Aruslanova,
  • E. Yu. Ashina,
  • O. Yu. Badina,
  • O. Yu. Barysheva,
  • T. I. Batluk,
  • A. S. Batchaeva,
  • R. A. Bashkinov,
  • A. M. Bitieva,
  • I. U. Bikhteev,
  • N. A. Borodulina,
  • M. V. Bragin,
  • V. A. Brazhnik,
  • A. M. Budu,
  • G. A. Bykova,
  • K. R. Vagapova,
  • D. D. Varlamova,
  • N. N. Vezikova,
  • E. A. Verbitskaya,
  • O. E. Vilkova,
  • E. A. Vinnikova,
  • V. V. Vustina,
  • E. A. Galova,
  • V. V. Genkel,
  • D. B. Giller,
  • E. I. Gorshenina,
  • E. V. Grigoryeva,
  • E. Yu. Gubareva,
  • G. M. Dabylova,
  • A. I. Demchenko,
  • O. Yu. Dolgikh,
  • M. Y. Duishobaev,
  • D. S. Evdokimov,
  • K. E. Egorova,
  • A. N. Ermilova,
  • A. E. Zheldybaeva,
  • N. V. Zarechnova,
  • Yu. D. Zimina,
  • S. Yu. Ivanova,
  • E. Yu. Ivanchenko,
  • M. V. Ilyina,
  • M. V. Kazakovtseva,
  • E. V. Kazymova,
  • Yu. S. Kalinina,
  • N. A. Kamardina,
  • A. M. Karachenova,
  • I. A. Karetnikov,
  • N. A. Karoli,
  • M. Kh. Karsiev,
  • D. S. Kaskaeva,
  • K. F. Kasymova,
  • J. B. Kerimbekova,
  • E. S. Kim,
  • N. V. Kiseleva,
  • D. A. Klimenko,
  • A. V. Klimova,
  • O. V. Kovalishena,
  • S. V. Kozlov,
  • E. V. Kolmakova,
  • T. P. Kolchinskaya,
  • M. I. Kolyadich,
  • O. V. Kondryakova,
  • M. P. Konoval,
  • D. Yu. Konstantinov,
  • E. A. Konstantinova,
  • V. A. Kordyukova,
  • E. V. Koroleva,
  • A. Yu. Kraposhina,
  • T. V. Kryukova,
  • A. P. Kuznetsova,
  • T. Yu. Kuzmina,
  • K. V. Kuzmichev,
  • Ch. K. Kulchoroeva,
  • T. V. Kuprina,
  • I. M. Kuranova,
  • L. V. Kurenkova,
  • N. Yu. Kurchugina,
  • N. A. Kushubakova,
  • V. I. Levankova,
  • A. A. Ledyaeva,
  • T. V. Lisun,
  • V. E. Lisyanskaya,
  • N. A. Lyubavina,
  • N. A. Magdeeva,
  • K. V. Mazalov,
  • V. I. Mayseenko,
  • A. S. Makarova,
  • A. M. Maripov,
  • N. V. Markov,
  • A. A. Marusina,
  • E. S. Melnikov,
  • A. I. Metlinskaya,
  • N. B. Moiseenko,
  • F. N. Muradova,
  • R. G. Muradyan,
  • Sh. N. Musaelyan,
  • E. S. Nekaeva,
  • N. M. Nikitina,
  • S. E. Nifontov,
  • E. Yu. Obolentseva,
  • A. A. Obukhova,
  • B. B. Ogurlieva,
  • A. A. Odegova,
  • Yu. V. Omarova,
  • N. A. Omurzakova,
  • Sh. O. Ospanova,
  • V. A. Pavlova,
  • E. V. Pakhomova,
  • L. D. Petrov,
  • S. S. Plastinina,
  • D. A. Platonov,
  • V. A. Pogrebetskaya,
  • D. V. Polyakov,
  • D. S. Polyakov,
  • E. V. Ponomarenko,
  • L. L. Popova,
  • A. A. Potanin,
  • N. A. Prokofieva,
  • Yu. D. Rabik,
  • N. A. Rakov,
  • A. N. Rakhimov,
  • N. A. Rozanova,
  • S. Serikbolkyzy,
  • Ya. A. Sidorkina,
  • A. A. Simonov,
  • V. V. Skachkova,
  • R. D. Skvortsova,
  • D. S. Skuridin,
  • D. V. Solovieva,
  • I. A. Solovieva,
  • I. M. Sukhomlinova,
  • A. G. Sushilova,
  • D. R. Tagaeva,
  • Yu. V. Titoikina,
  • E. P. Tikhonova,
  • D. S. Tokmin,
  • A. A. Tolmacheva,
  • M. S. Torgunakova,
  • K. V. Trenogina,
  • N. A. Trostyanetskaya,
  • D. A. Trofimov,
  • M. A. Trubnikova,
  • A. A. Tulichev,
  • A. T. Tursunova,
  • N. D. Ulanova,
  • O. V. Fatenkov,
  • O. V. Fedorishina,
  • T. S. Fil,
  • I. Yu. Fomina,
  • I. S. Fominova,
  • I. A. Frolova,
  • S. M. Tsvinger,
  • V. V. Tsoma,
  • M. B. Cholponbaeva,
  • T. I. Chudinovskikh,
  • I. V. Shavrin,
  • O. A. Shevchenko,
  • D. R. Shikhaliev,
  • E. A. Shishkina,
  • K. Yu Shishkov,
  • S. Yu. Shcherbakov,
  • G. V. Shcherbakova,
  • E. A. Yausheva

DOI
https://doi.org/10.15829/1560-4071-2022-5042
Journal volume & issue
Vol. 27, no. 9

Abstract

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Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry.Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation.Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of <2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<1,4 mmol/l), mortality was 13,04%, which was significantly higher than in patients with LDL-C ≥1,4 mmol/l (6,32%, p=0,047).Conclusion. A decrease in LDL-C in the acute period is significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. Determination of LDL-C can be included in the examination program for patients with COVID-19. However, the predictive value of this parameter requires further study in prospective clinical studies.

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