Nature Communications (Feb 2023)
SVEP1 is an endogenous ligand for the orphan receptor PEAR1
- Jared S. Elenbaas,
- Upasana Pudupakkam,
- Katrina J. Ashworth,
- Chul Joo Kang,
- Ved Patel,
- Katherine Santana,
- In-Hyuk Jung,
- Paul C. Lee,
- Kendall H. Burks,
- Junedh M. Amrute,
- Robert P. Mecham,
- Carmen M. Halabi,
- Arturo Alisio,
- Jorge Di Paola,
- Nathan O. Stitziel
Affiliations
- Jared S. Elenbaas
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Upasana Pudupakkam
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Katrina J. Ashworth
- Division of Pediatric Hematology Oncology, Washington University in St. Louis
- Chul Joo Kang
- McDonnell Genome Institute, Washington University School of Medicine
- Ved Patel
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Katherine Santana
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- In-Hyuk Jung
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Paul C. Lee
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Kendall H. Burks
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Junedh M. Amrute
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Robert P. Mecham
- Department of Cell Biology and Physiology, Washington University School of Medicine
- Carmen M. Halabi
- Department of Cell Biology and Physiology, Washington University School of Medicine
- Arturo Alisio
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- Jorge Di Paola
- Division of Pediatric Hematology Oncology, Washington University in St. Louis
- Nathan O. Stitziel
- Division of Cardiology, Department of Medicine, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36486-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
SVEP1 is linked to numerous human diseases, though its disease-promoting mechanism has remained unclear. Here, the authors identify SVEP1 as a ligand for the orphan receptor PEAR1 and provide insight into the role of this interaction in cardiovascular disease.
