Disseminated herpes simplex virus type 1 infection manifested as extensive oral ulcers, pneumonitis, and ileo-colitis in a neutropenic patient post-chemotherapy for osteosarcoma
Samadhi Patamatamkul,
Narittee Sukswai,
Onjira Mangkalamanee,
Rongpong Plongla
Affiliations
Samadhi Patamatamkul
Department of Medicine, Faculty of Medicine, Suddhavej Hospital, Mahasarakham University, Maha Sarakham, Thailand; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial, Thai Red Cross Society, Bangkok, Thailand; Corresponding author at: Department of Medicine, Faculty of Medicine, Suddhavej Hospital, Mahasarakham University, Maha Sarakham, Thailand.
Narittee Sukswai
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Onjira Mangkalamanee
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial, Thai Red Cross Society, Bangkok, Thailand
Rongpong Plongla
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial, Thai Red Cross Society, Bangkok, Thailand; Center of Excellence in Antimicrobial Resistance and Stewardship, Chulalongkorn University, Bangkok, Thailand; Correspondence to: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Herpes simplex virus (HSV) is a common cause of recurrent oropharyngeal ulcers or stomatitis resulting from the reactivation of latent infection since childhood. Extensive ulceration and dissemination to vital organs such as pneumonitis or colitis is mostly encountered among hematologic malignancy or hematologic stem cell transplants. We hereby reported a case with osteosarcoma who developed disseminated HSV infection during neutropenia after chemotherapy.
