EFFECT OF IMMUNOMODULATOR AND DIFFERENT ROUTES OF VACCINATION ON ANTIBODY TITERS AGAINST NEWCASTLE DISEASE IN UNIGOLD BIRDS

Abstract

The study was conducted to evaluate the effect of Lisovit supplementation and compare efficacy of different routes of vaccination on immunity against ND in Uni Gold birds. 180 UniGold adult birds (36th to 40th week of age) were randomly divided into 12 groups having 15 birds in each group (6 groups of male and female birds). Group A, C, E, G, I and L were given lisovit @ 200mg/kg of body weight. Group C, D, J and J were vaccinated through oral route (drinking water). Group E, F, K and L were vaccinated through ocular route (eye drop). One day before before vaccination (0 day) geometric mean titer in group A, B, C, D, E, F, G, H, I, J, K and L, was 9.12, 18.19, 95.49, 18.19, 47.86, 41.68, 23.98, 31.62, 165.95, 36.3, 18.19 and 36.3 respectively. At 7th day GMT in these groups was 18.19, 12.02, 165.95, 144.54, 72.44, 47.86, 41.68, 23.98, 144.54, 125.89, 380.18 and 218.77 respectively. At 30th day GMT in these groups was 36.3, 20.89, 288.4, 218.77, 218.77, 23.98, 83.17, 47.86, 125.89, 436.51, 190.54 and 144.54, respectively. At 45th day GMT in these group was 5.24, 12.02, 7.94, 31.62, 41.68, 13.8, 20.89, 54.95, 95.49, 54.95, 125.89 and 72.44, respectively. At 0 day the ELISA mean titer value in group B, E, H and L was 1378.4, 6083.4, 7127.6 and 6910.0 respectively. At 7th day ELISA titer in these group was 1981.4, 6346.5, 1285.8 and 10051.6 respectively. At 30th day ELISA titer in these groups was 1650.2, 4155.2, 266.4 and 7487.6 respectively. At 45th day ELISA titers in these groups were 654.0, 2838.2, 1990.8 and 4597.4, respectively.

Keywords

• antibody
• immune-modulator
• newcastle disease
• routes
• unigold
• vaccination