Nature Communications (Aug 2022)
Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein
- Jelle van Schooten,
- Elinaz Farokhi,
- Anna Schorcht,
- Tom L. G. M. van den Kerkhof,
- Hongmei Gao,
- Patricia van der Woude,
- Judith A. Burger,
- Tim G. Rijkhold Meesters,
- Tom Bijl,
- Riham Ghalaiyini,
- Hannah L. Turner,
- Jessica Dorning,
- Barbera D. C. van Schaik,
- Antoine H. C. van Kampen,
- Celia C. Labranche,
- Robyn L. Stanfield,
- Devin Sok,
- David C. Montefiori,
- Dennis R. Burton,
- Michael S. Seaman,
- Gabriel Ozorowski,
- Ian A. Wilson,
- Rogier W. Sanders,
- Andrew B. Ward,
- Marit J. van Gils
Affiliations
- Jelle van Schooten
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Elinaz Farokhi
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Anna Schorcht
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Tom L. G. M. van den Kerkhof
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Hongmei Gao
- Department of Surgery, Duke University Medical Center
- Patricia van der Woude
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Judith A. Burger
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Tim G. Rijkhold Meesters
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Tom Bijl
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Riham Ghalaiyini
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Hannah L. Turner
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Jessica Dorning
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Barbera D. C. van Schaik
- Bioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam
- Antoine H. C. van Kampen
- Bioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam
- Celia C. Labranche
- Department of Surgery, Duke University Medical Center
- Robyn L. Stanfield
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Devin Sok
- Department of Immunology and Microbiology, The Scripps Research Institute
- David C. Montefiori
- Department of Surgery, Duke University Medical Center
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- Michael S. Seaman
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Gabriel Ozorowski
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Ian A. Wilson
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Rogier W. Sanders
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- Andrew B. Ward
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Marit J. van Gils
- Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam
- DOI
- https://doi.org/10.1038/s41467-022-32208-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
HIV-1 vaccine design aims to induce broadly neutralizing antibodies such as IOMA, the only described antibody in its class. Here, the authors present the isolation, characterisation and structure of three additional antibodies within the IOMA class
