Frontiers in Cellular and Infection Microbiology (Aug 2022)
Echinococcus granulosus: The establishment of the metacestode in the liver is associated with control of the CD4+ T-cell-mediated immune response in patients with cystic echinococcosis and a mouse model
- Xinling Hou,
- Xinling Hou,
- Yang Shi,
- Yang Shi,
- Xuejiao Kang,
- Xuejiao Kang,
- Zibigu· Rousu,
- Zibigu· Rousu,
- Dewei Li,
- Dewei Li,
- Maolin Wang,
- Maolin Wang,
- Maolin Wang,
- Abidan· Ainiwaer,
- Abidan· Ainiwaer,
- Xuran Zheng,
- Xuran Zheng,
- MingKun Wang,
- MingKun Wang,
- Bahejiang· Jiensihan,
- Bahejiang· Jiensihan,
- Liang Li,
- Jing Li,
- Hui Wang,
- Hui Wang,
- Hui Wang,
- Chuanshan Zhang,
- Chuanshan Zhang,
- Chuanshan Zhang
Affiliations
- Xinling Hou
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Xinling Hou
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Yang Shi
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Yang Shi
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Xuejiao Kang
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Xuejiao Kang
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Zibigu· Rousu
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Zibigu· Rousu
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Dewei Li
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Dewei Li
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Maolin Wang
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Maolin Wang
- Xinjiang Key Laboratory of Echinococcosis, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, and World Health Organization Collaborating Centre on Prevention and Case Management of Echinococcosis, Urumqi, China
- Maolin Wang
- Department of Hepatic Hydatid and Hepatobiliary Surgery, Digestive and Vascular Surgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Abidan· Ainiwaer
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Abidan· Ainiwaer
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Xuran Zheng
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Xuran Zheng
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- MingKun Wang
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- MingKun Wang
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Bahejiang· Jiensihan
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Bahejiang· Jiensihan
- Xinjiang Key Laboratory of Echinococcosis, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, and World Health Organization Collaborating Centre on Prevention and Case Management of Echinococcosis, Urumqi, China
- Liang Li
- Xinjiang Key Laboratory of Echinococcosis, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, and World Health Organization Collaborating Centre on Prevention and Case Management of Echinococcosis, Urumqi, China
- Jing Li
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Hui Wang
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Hui Wang
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Hui Wang
- Xinjiang Key Laboratory of Echinococcosis, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, and World Health Organization Collaborating Centre on Prevention and Case Management of Echinococcosis, Urumqi, China
- Chuanshan Zhang
- State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- Chuanshan Zhang
- Basic Medical College, Xinjiang Medical University, Urumqi, China
- Chuanshan Zhang
- Xinjiang Key Laboratory of Echinococcosis, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, and World Health Organization Collaborating Centre on Prevention and Case Management of Echinococcosis, Urumqi, China
- DOI
- https://doi.org/10.3389/fcimb.2022.983119
- Journal volume & issue
-
Vol. 12
Abstract
The larval stage of the tapeworm Echinococcus granulosus sensu lato (E. granulosus s.l.) caused a chronic infection, known as cystic echinococcosis (CE), which is a worldwide public health problem. The human secondary CE is caused by the dissemination of protoscoleces (PSCs) when fertile cysts are accidentally ruptured, followed by development of PSCs into new metacestodes. The local immune mechanisms responsible for the establishment and established phases after infection with E. granulosus s.l. are not clear. Here, we showed that T cells were involved in the formation of the immune environment in the liver in CE patients and Echinococcus granulosus sensu strict (E. granulosus s.s.)-infected mice, with CD4+ T cells being the dominant immune cells; this process was closely associated with cyst viability and establishment. Local T2-type responses in the liver were permissive for early infection establishment by E. granulosus s.s. between 4 and 6 weeks in the experimental model. CD4+ T-cell deficiency promoted PSC development into cysts in the liver in E. granulosus s.s.-infected mice. In addition, CD4+ T-cell-mediated cellular immune responses and IL-10-producing CD8+ T cells play a critical role in the establishment phase of secondary E. granulosus s.s. PSC infection. These data contribute to the understanding of local immune responses to CE and the design of new therapies by restoring effective immune responses and blocking evasion mechanisms during the establishment phase of infection.
Keywords
