Nature Communications (Jul 2021)
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis
- Mengfei Liu,
- Sheng Cao,
- Li He,
- Jinhang Gao,
- Juan P. Arab,
- Huarui Cui,
- Weixia Xuan,
- Yandong Gao,
- Tejasav S. Sehrawat,
- Feda H. Hamdan,
- Meritxell Ventura-Cots,
- Josepmaria Argemi,
- William C. K. Pomerantz,
- Steven A. Johnsen,
- Jeong-Heon Lee,
- Fei Gao,
- Tamas Ordog,
- Philippe Mathurin,
- Alexander Revzin,
- Ramon Bataller,
- Huihuang Yan,
- Vijay H. Shah
Affiliations
- Mengfei Liu
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Sheng Cao
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Li He
- Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Jinhang Gao
- Lab of Gastroenterology and Hepatology, West China Hospital, Sichuan University
- Juan P. Arab
- Department of Gastroenterology and Hepatology, School of Medicine of the Pontificia Universidad Católica de Chile
- Huarui Cui
- Department of Chemistry, University of Minnesota
- Weixia Xuan
- Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital
- Yandong Gao
- Department of Physiology and Biomedical Engineering, Mayo Clinic
- Tejasav S. Sehrawat
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Feda H. Hamdan
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Meritxell Ventura-Cots
- Department of Gastroenterology Hepatology and Nutrition, University of Pittsburgh
- Josepmaria Argemi
- Department of Gastroenterology Hepatology and Nutrition, University of Pittsburgh
- William C. K. Pomerantz
- Department of Chemistry, University of Minnesota
- Steven A. Johnsen
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Jeong-Heon Lee
- Center for Individualized Medicine, Mayo Clinic
- Fei Gao
- Center for Individualized Medicine, Mayo Clinic
- Tamas Ordog
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Philippe Mathurin
- University of Lille
- Alexander Revzin
- Department of Physiology and Biomedical Engineering, Mayo Clinic
- Ramon Bataller
- Department of Gastroenterology Hepatology and Nutrition, University of Pittsburgh
- Huihuang Yan
- Center for Individualized Medicine, Mayo Clinic
- Vijay H. Shah
- Division of Gastroenterology and Hepatology, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-021-24843-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Alcoholic hepatitis is characterized by intense liver inflammation driven by excessive cytokines and chemokines production and immune cell infiltration. Here the authors identify a super-enhancer that regulates the expression of multiple CXCL chemokines in alcoholic hepatitis and may be a potential therapeutic target.
