CYP polymorphisms and pathological conditions related to chronic exposure to organochlorine pesticides

Anca Oana Docea; Loukia Vassilopoulou; Domniki Fragou; Andreea Letitia Arsene; Concettina Fenga; Leda Kovatsi; Dimitrios Petrakis; Valerii N. Rakitskii; Alexander E. Nosyrev; Boris N. Izotov; Kirill S. Golokhvast; Alexander M. Zakharenko; Antonis Vakis; Christina Tsitsimpikou; Nikolaos Drakoulis

Toxicology Reports (Jan 2017)

CYP polymorphisms and pathological conditions related to chronic exposure to organochlorine pesticides

Anca Oana Docea,
Loukia Vassilopoulou,
Domniki Fragou,
Andreea Letitia Arsene,
Concettina Fenga,
Leda Kovatsi,
Dimitrios Petrakis,
Valerii N. Rakitskii,
Alexander E. Nosyrev,
Boris N. Izotov,
Kirill S. Golokhvast,
Alexander M. Zakharenko,
Antonis Vakis,
Christina Tsitsimpikou,
Nikolaos Drakoulis

Affiliations

Anca Oana Docea: Department of Toxicology, University of Medicine and Pharmacy, Faculty of Pharmacy, 2 Petru Rares, 200349, Craiova, Romania
Loukia Vassilopoulou: Department of Toxicology and Forensic Sciences, Medical School, University of Crete, Heraklion, Greece
Domniki Fragou: Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, Greece
Andreea Letitia Arsene: Department of Microbiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Concettina Fenga: Department of Biomedical and Dental Sciences and Morphofunctional Imaging â Occupational Medicine Section â University of Messina, 98125 Messina, Italy
Leda Kovatsi: Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, Greece
Dimitrios Petrakis: Paediatric Surgeon, Heraklion, Greece
Valerii N. Rakitskii: Federal Scientific Center of Hygiene, F.F. Erisman, Moscow, Russian Federation
Alexander E. Nosyrev: Central Chemical Laboratory of Toxicology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Boris N. Izotov: Central Chemical Laboratory of Toxicology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Kirill S. Golokhvast: Scientific Educational Center of Nanotechnology, Far Eastern Federal University, Vladivostok, Russian Federation
Alexander M. Zakharenko: Scientific Educational Center of Nanotechnology, Far Eastern Federal University, Vladivostok, Russian Federation
Antonis Vakis: Department of Neurosurgery, University of Crete, Medical School, Heraklion University Hospital, Voutes, 71 021 Heraklion, Crete, Greece
Christina Tsitsimpikou: Department of Dangerous Substances, Mixtures and Articles, Directorate of Energy, Industrial and Chemical Products, General Chemical State Laboratory of Greece, Athens, Greece
Nikolaos Drakoulis: Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Greece; Corresponding author at: Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, Greece.

Journal volume & issue: Vol. 4
pp. 335 – 341

Abstract

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The association between genetic variations in the cytochrome P450 (CYP) family genes and pathological conditions related to long-term exposure to organochlorine compounds (OCs) deserves further elucidation. OCs are persistent organic pollutants with bioaccumulative and lipophilic characteristics. They can act as endocrine disruptors and perturb cellular mechanisms. Prolonged exposure to OCs has been associated with different pathological manifestations. CYP genes are responsible for transcribing enzymes essential in xenobiotic metabolism. Therefore, polymorphisms in these genetic sequences a. alter the metabolic pathways, b. induce false cellular responses, and c. may provoke pathological conditions. The main aim of this review is to define the interaction between parameters a, b and c at a mechanistic/molecular level, with references in clinical cases. Keywords: Organochlorine compounds, Cytochrome P450, Genetic polymorphisms, Pathogenesis, Environmental pollutants

Published in Toxicology Reports

ISSN: 2214-7500 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Public aspects of medicine: Toxicology. Poisons
Website: http://www.journals.elsevier.com/toxicology-reports/

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