Nature Communications (Dec 2017)
Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
- Hsu-Wen Chao,
- Masao Doi,
- Jean-Michel Fustin,
- Huatao Chen,
- Kimihiko Murase,
- Yuki Maeda,
- Hida Hayashi,
- Rina Tanaka,
- Maho Sugawa,
- Naoki Mizukuchi,
- Yoshiaki Yamaguchi,
- Jun-ichirou Yasunaga,
- Masao Matsuoka,
- Mashito Sakai,
- Michihiro Matsumoto,
- Shinshichi Hamada,
- Hitoshi Okamura
Affiliations
- Hsu-Wen Chao
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Masao Doi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Jean-Michel Fustin
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Huatao Chen
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Kimihiko Murase
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Yuki Maeda
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Hida Hayashi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Rina Tanaka
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Maho Sugawa
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Naoki Mizukuchi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Yoshiaki Yamaguchi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Jun-ichirou Yasunaga
- Laboratory of Virus Control, Institute for Virus Research, Kyoto University
- Masao Matsuoka
- Laboratory of Virus Control, Institute for Virus Research, Kyoto University
- Mashito Sakai
- Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
- Michihiro Matsumoto
- Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
- Shinshichi Hamada
- Department of Pathology, Otsu City Hospital
- Hitoshi Okamura
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-017-02207-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated protein kinase phosphatase 1.
