THE RELATIONSHIP BETWEEN BAD OBSTETRIC HISTORY AND THROMBOPHILI

Abstract

The aim was to evaluate the relationship of recurring miscarriages and in utero mort fetus cases over 20 weeks of pregnancy (except for those caused by a systemic disease or a known pathology) with thrombophilic conditions. Our study was conducted on the patients who were admitted to our clinic with for follow ups or investigation of recurring pregnancy losses. The included patients had had at least 2 fetal losses over 8 weeks into their pregnancy or at least one loss over the 20th gestational week and gave histories of hypertensive pathologies of pregnancy such as preeclampsia or eclampsia. The control group comprised 81 patients who had at least one pregnancy without any complication or fetal loss histories. In our study, the ratios of Factor V Leiden mutation in the study group (106 cases) and the control group (81 cases) were %12 and %1.3 (p=0.01) respectively. In the patient group, the MTHFR homozygous mutation was seen 3.3 times as much and Factor V Leiden heterozygous gene mutation was determined to be seen 8.3 as much as the control group. There was a significant difference between the study and control groups in terms of Protein C and S activity (p<0.0001 ve p<0.001). In the study group, the detection rate of Protein C levels <%65 was 5.2 times more(OR 5.2 2.7-12.49), and the Protein S activity was 12.17 times higher than the control group. Thrombophilic cases may play many roles in the pathologies which arise during pregnancies.

Keywords

• thrombophilia
• recurring miscarriages