Dynamical properties and tumor clearance conditions for a nine-dimensional model of bladder cancer immunotherapy

Abstract

Understanding the global interaction dynamics between tumor and the immunesystem plays a key role in the advancement of cancer therapy.Bunimovich-Mendrazitsky et al. (2015) developed a mathematical model for thestudy of the immune system response to combined therapy for bladder cancerwith Bacillus Calmette-Guérin (BCG) and interleukin-2 (IL-2) . Weutilized a mathematical approach for bladder cancer treatment model forderivation of ultimate upper and lower bounds and proving dissipativityproperty in the sense of Levinson. Furthermore, tumor clearance conditionsfor BCG treatment of bladder cancer are presented. Our method is based onlocalization of compact invariant sets and may be exploited for a predictionof the cells populations dynamics involved into the model.

Keywords

• il-2
• bcg
• localization
• ultimate dynamics
• compact invariant set.
• dynamic modelling
• combined therapy