Nature Communications (Jan 2021)

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

  • Martina K. Ried,
  • Rebekka Wild,
  • Jinsheng Zhu,
  • Joka Pipercevic,
  • Kristina Sturm,
  • Larissa Broger,
  • Robert K. Harmel,
  • Luciano A. Abriata,
  • Ludwig A. Hothorn,
  • Dorothea Fiedler,
  • Sebastian Hiller,
  • Michael Hothorn

DOI
https://doi.org/10.1038/s41467-020-20681-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Plants regulate phosphate homeostasis via the interaction of PHR transcription factors with SPX receptors bound to inositol pyrophosphate signaling molecules. Here the authors show that inositol pyrophosphate-bound SPX interacts with the coiled-coil domain of PHR, which regulates the oligomerization and activity of the transcription factor.