Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model

Materials. 2016;9(2):97 DOI 10.3390/ma9020097

 

Journal Homepage

Journal Title: Materials

ISSN: 1996-1944 (Print)

Publisher: MDPI AG

LCC Subject Category: Technology: Electrical engineering. Electronics. Nuclear engineering | Technology: Engineering (General). Civil engineering (General) | Science: Natural history (General): Microscopy | Science: Physics: Descriptive and experimental mechanics

Country of publisher: Switzerland

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Jiyeon Roh (BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 03722, Korea)
Ji-Youn Kim (Department of Dental Hygiene, College of Health Science, Gachon University, Incheon 21936, Korea)
Young-Muk Choi (Meta-Biomed Co., Ltd. Institute, 270 Osongsaengmyeong1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk 28161, Korea)
Seong-Min Ha (Meta-Biomed Co., Ltd. Institute, 270 Osongsaengmyeong1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk 28161, Korea)
Kyoung-Nam Kim (BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 03722, Korea)
Kwang-Mahn Kim (BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 03722, Korea)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 11 weeks

 

Abstract | Full Text

The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with β-tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCPTM (HA:β-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material.