Cell Death and Disease (Apr 2017)
RETRACTED ARTICLE: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis
- Jihua Han,
- Changming Xie,
- Tiemin Pei,
- Jiabei Wang,
- Yaliang Lan,
- Kaihua Huang,
- Yifeng Cui,
- Fengyue Wang,
- Jiewu Zhang,
- Shangha Pan,
- Yingjian Liang,
- Tongsen Zhen,
- Ruipeng Song,
- Boshi Sun,
- Yuejin Li,
- Huawen Shi,
- Guangchao Yang,
- Xirui Liu,
- Mingxi Zhu,
- Yan Wang,
- Keyu Li,
- Yao Liu,
- Fanzheng Meng,
- Fei Liao,
- Xianzhi Meng,
- Xuehui Hong,
- Lianxin Liu
Affiliations
- Jihua Han
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Changming Xie
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Tiemin Pei
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Jiabei Wang
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Yaliang Lan
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Kaihua Huang
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Yifeng Cui
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Fengyue Wang
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Jiewu Zhang
- Department of Head and Neck Surgery, The Third Affiliated Hospital of Harbin Medical University
- Shangha Pan
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Yingjian Liang
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Tongsen Zhen
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Ruipeng Song
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Boshi Sun
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Yuejin Li
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Huawen Shi
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Guangchao Yang
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Xirui Liu
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Mingxi Zhu
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Yan Wang
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Keyu Li
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Yao Liu
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Fanzheng Meng
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Fei Liao
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Xianzhi Meng
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- Xuehui Hong
- Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University
- Lianxin Liu
- Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University
- DOI
- https://doi.org/10.1038/cddis.2017.126
- Journal volume & issue
-
Vol. 8,
no. 4
pp. e2736 – e2736
Abstract
Abstract Adherens junctions-associated protein 1 (AJAP1) is an integral membrane protein that is thought to function as a tumor suppressor in various malignancies. Downregulation of AJAP1 mRNA levels may predict recurrence in hepatocellular carcinoma (HCC) patients, but the underlying molecular mechanism is unknown. This was addressed in the present study by examining the role of AJAP1 in HCC cell proliferation, migration, and invasion in vitro as well as in human specimens and mouse xenograft model. We found that AJAP1 expression was reduced in HCC cells and human HCC tissue, which was associated with metastasis. AJAP1 overexpression inhibited HCC progression and metastasis, while its silencing had the opposite effect both in vitro and in vivo. Furthermore, AJAP1 blocked epithelial–to–mesenchymal transition by interacting with β-catenin and inhibiting its nuclear translocation, which suppressed zinc finger E-box binding homeobox 1 (ZEB1) transcription. These results indicate that AJAP1 inhibits HCC metastasis, and is thus a potential therapeutic target for HCC treatment.
