Nature Communications (May 2021)
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
- Peter Peneder,
- Adrian M. Stütz,
- Didier Surdez,
- Manuela Krumbholz,
- Sabine Semper,
- Mathieu Chicard,
- Nathan C. Sheffield,
- Gaelle Pierron,
- Eve Lapouble,
- Marcus Tötzl,
- Bekir Ergüner,
- Daniele Barreca,
- André F. Rendeiro,
- Abbas Agaimy,
- Heidrun Boztug,
- Gernot Engstler,
- Michael Dworzak,
- Marie Bernkopf,
- Sabine Taschner-Mandl,
- Inge M. Ambros,
- Ola Myklebost,
- Perrine Marec-Bérard,
- Susan Ann Burchill,
- Bernadette Brennan,
- Sandra J. Strauss,
- Jeremy Whelan,
- Gudrun Schleiermacher,
- Christiane Schaefer,
- Uta Dirksen,
- Caroline Hutter,
- Kjetil Boye,
- Peter F. Ambros,
- Olivier Delattre,
- Markus Metzler,
- Christoph Bock,
- Eleni M. Tomazou
Affiliations
- Peter Peneder
- St. Anna Children’s Cancer Research Institute (CCRI)
- Adrian M. Stütz
- St. Anna Children’s Cancer Research Institute (CCRI)
- Didier Surdez
- INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Manuela Krumbholz
- Department of Pediatrics, University Hospital Erlangen
- Sabine Semper
- Department of Pediatrics, University Hospital Erlangen
- Mathieu Chicard
- INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Nathan C. Sheffield
- Center for Public Health Genomics, University of Virginia
- Gaelle Pierron
- Unité de Génétique Somatique, Service d’oncogénétique, Institut Curie, Centre Hospitalier
- Eve Lapouble
- Unité de Génétique Somatique, Service d’oncogénétique, Institut Curie, Centre Hospitalier
- Marcus Tötzl
- St. Anna Children’s Cancer Research Institute (CCRI)
- Bekir Ergüner
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Daniele Barreca
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- André F. Rendeiro
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Abbas Agaimy
- Institute of Pathology, University Hospital Erlangen
- Heidrun Boztug
- St. Anna Kinderspital, Department of Pediatrics, Medical University
- Gernot Engstler
- St. Anna Kinderspital, Department of Pediatrics, Medical University
- Michael Dworzak
- St. Anna Kinderspital, Department of Pediatrics, Medical University
- Marie Bernkopf
- St. Anna Children’s Cancer Research Institute (CCRI)
- Sabine Taschner-Mandl
- St. Anna Children’s Cancer Research Institute (CCRI)
- Inge M. Ambros
- St. Anna Children’s Cancer Research Institute (CCRI)
- Ola Myklebost
- Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital
- Perrine Marec-Bérard
- Pediatric Department, Hematology and Oncology Pediatric Institute, Centre Léon Bérard
- Susan Ann Burchill
- Children’s Cancer Research Group, Leeds Institute of Medical Research, St. James’s University Hospital
- Bernadette Brennan
- Department of Pediatric Oncology, Royal Manchester Children’s Hospital
- Sandra J. Strauss
- Department of Oncology, UCL Cancer Institute
- Jeremy Whelan
- Department of Oncology, University College London Hospital
- Gudrun Schleiermacher
- INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Christiane Schaefer
- University Hospital Essen, Pediatrics III, West German Cancer Centre
- Uta Dirksen
- University Hospital Essen, Pediatrics III, West German Cancer Centre
- Caroline Hutter
- St. Anna Children’s Cancer Research Institute (CCRI)
- Kjetil Boye
- Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital
- Peter F. Ambros
- St. Anna Children’s Cancer Research Institute (CCRI)
- Olivier Delattre
- INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Markus Metzler
- Department of Pediatrics, University Hospital Erlangen
- Christoph Bock
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Eleni M. Tomazou
- St. Anna Children’s Cancer Research Institute (CCRI)
- DOI
- https://doi.org/10.1038/s41467-021-23445-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Liquid biopsies enable minimally invasive applications for diagnosis and treatment monitoring. Here the authors analyse fragmentation patterns of circulating tumour DNA on multiple levels and develop a bioinformatic tool, LIQUORICE, to accurately detect and classify paediatric cancers with low mutational burden.
