Nature Communications (Dec 2021)
The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
- Matthieu Lacroix,
- Laetitia K. Linares,
- Natalia Rueda-Rincon,
- Katarzyna Bloch,
- Michela Di Michele,
- Carlo De Blasio,
- Caroline Fau,
- Laurie Gayte,
- Emilie Blanchet,
- Aline Mairal,
- Rita Derua,
- Fernando Cardona,
- Diane Beuzelin,
- Jean-Sebastien Annicotte,
- Nelly Pirot,
- Adeline Torro,
- Francisco J. Tinahones,
- Florence Bernex,
- Justine Bertrand-Michel,
- Dominique Langin,
- Lluis Fajas,
- Johannes V. Swinnen,
- Laurent Le Cam
Affiliations
- Matthieu Lacroix
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Laetitia K. Linares
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Natalia Rueda-Rincon
- KU Leuven–University of Leuven, Department of Oncology, Laboratory of Lipid Metabolism and Cancer
- Katarzyna Bloch
- KU Leuven–University of Leuven, Department of Oncology, Laboratory of Lipid Metabolism and Cancer
- Michela Di Michele
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Carlo De Blasio
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Caroline Fau
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Laurie Gayte
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Emilie Blanchet
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Aline Mairal
- I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III – Paul Sabatier (UPS)
- Rita Derua
- KU Leuven–University of Leuven, Department of Cellular and Molecular Medicine
- Fernando Cardona
- Department of Surgical Specialties, Biochemistry and Immunology School of Medicine, University of Malaga
- Diane Beuzelin
- I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III – Paul Sabatier (UPS)
- Jean-Sebastien Annicotte
- Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID
- Nelly Pirot
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Adeline Torro
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Francisco J. Tinahones
- CIBER of Physiopathology, Obesity and Nutrition (CIBEROBN), Málaga, Spain; Unidad de Gestion Clinica de Endocrinologia y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Clinico Virgen de la Victoria
- Florence Bernex
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- Justine Bertrand-Michel
- I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III – Paul Sabatier (UPS)
- Dominique Langin
- I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III – Paul Sabatier (UPS)
- Lluis Fajas
- Center for Integrative Genomics, University of Lausanne
- Johannes V. Swinnen
- KU Leuven–University of Leuven, Department of Oncology, Laboratory of Lipid Metabolism and Cancer
- Laurent Le Cam
- IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier
- DOI
- https://doi.org/10.1038/s41467-021-27307-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood. Here the authors report that the deletion of the multifunctional protein E4F1 is protective against diet-induced obesity in mice, and E4F1 regulates adipocyte lipid metabolism through p53.
