Nature Communications (Feb 2016)
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
- Christian K. Holm,
- Stine H. Rahbek,
- Hans Henrik Gad,
- Rasmus O. Bak,
- Martin R. Jakobsen,
- Zhaozaho Jiang,
- Anne Louise Hansen,
- Simon K. Jensen,
- Chenglong Sun,
- Martin K. Thomsen,
- Anders Laustsen,
- Camilla G. Nielsen,
- Kasper Severinsen,
- Yingluo Xiong,
- Dara L. Burdette,
- Veit Hornung,
- Robert Jan Lebbink,
- Mogens Duch,
- Katherine A. Fitzgerald,
- Shervin Bahrami,
- Jakob Giehm Mikkelsen,
- Rune Hartmann,
- Søren R. Paludan
Affiliations
- Christian K. Holm
- Department of Biomedicine, Aarhus University
- Stine H. Rahbek
- Department of Biomedicine, Aarhus University
- Hans Henrik Gad
- Aarhus Research Center for Innate Immunity, Aarhus University
- Rasmus O. Bak
- Department of Biomedicine, Aarhus University
- Martin R. Jakobsen
- Department of Biomedicine, Aarhus University
- Zhaozaho Jiang
- Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts
- Anne Louise Hansen
- Department of Biomedicine, Aarhus University
- Simon K. Jensen
- Department of Biomedicine, Aarhus University
- Chenglong Sun
- Department of Biomedicine, Aarhus University
- Martin K. Thomsen
- Department of Biomedicine, Aarhus University
- Anders Laustsen
- Department of Biomedicine, Aarhus University
- Camilla G. Nielsen
- Department of Biomedicine, Aarhus University
- Kasper Severinsen
- Psychiatric Department, Aarhus University Hospital
- Yingluo Xiong
- Department of Biomedicine, Aarhus University
- Dara L. Burdette
- Department of Molecular and Cellular Biology, University of California
- Veit Hornung
- Institute of Molecular Medicine, University Hospital, University of Bonn
- Robert Jan Lebbink
- Department of Medical Microbiology, University Medical Center
- Mogens Duch
- Department of Molecular Biology and Genetics, Aarhus University
- Katherine A. Fitzgerald
- Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts
- Shervin Bahrami
- Department of Molecular Biology and Genetics, Aarhus University
- Jakob Giehm Mikkelsen
- Department of Biomedicine, Aarhus University
- Rune Hartmann
- Aarhus Research Center for Innate Immunity, Aarhus University
- Søren R. Paludan
- Department of Biomedicine, Aarhus University
- DOI
- https://doi.org/10.1038/ncomms10680
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus infection in a cGAS-independent manner.
