Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report
Nektarios Koufopoulos,
Dionysios Dimas,
Foteini Antoniadou,
Kyparissia Sitara,
Dimitrios Balalis,
Ioannis Boutas,
Alina Roxana Gouloumis,
Adamantia Kontogeorgi,
Lubna Khaldi
Affiliations
Nektarios Koufopoulos
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Dionysios Dimas
Breast Unit, Athens Medical Center, Psychiko Clinic, 11525 Athens, Greece
Foteini Antoniadou
Department of Pathology, “Alexandra” General Hospital, 11528 Athens, Greece
Kyparissia Sitara
Department of Internal Medicine, “Elpis” General Hospital of Athens, 11522 Athens, Greece
Dimitrios Balalis
Department of Surgical Oncology, Saint Savvas Anticancer Hospital of Athens, 11522 Athens, Greece
Ioannis Boutas
Breast Unit, Rea Maternity Hospital, P. Faliro, 17564 Athens, Greece
Alina Roxana Gouloumis
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Adamantia Kontogeorgi
Third Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Lubna Khaldi
Department of Pathology, Saint Savvas Anticancer Hospital of Athens, 11522 Athens, Greece
Microglandular adenosis is a non-lobulocentric haphazard proliferation of small round glands composed of a single layer of flat to cuboidal epithelial cells. The glandular structures lack a myoepithelial layer; however, they are surrounded by a basement membrane. Its clinical course is benign, when it is not associated with invasive carcinoma. In around 30% of cases, there is a gradual transition to atypical microglandular adenosis, carcinoma in situ, and invasive breast carcinoma of several different histologic subtypes, including an invasive carcinoma of no special type, metaplastic matrix-producing carcinoma, secretory carcinoma, metaplastic carcinoma with squamous differentiation, acinic cell carcinoma, spindle cell carcinoma, and adenoid cystic carcinoma. Recent molecular studies suggest that microglandular adenosis is a non-obligate precursor of triple-negative breast carcinomas. In this manuscript, we present a unique case of microglandular adenosis associated with metaplastic matrix-producing carcinoma and HER-2 neu oncoprotein positive pleomorphic lobular carcinoma in situ with apocrine differentiation in a 79-year-old patient.
