Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates

Abstract

Copper-catalysed annulation of allenylidenes provides an opportunity to target the alpha, beta, or gamma positions of the allenylidene, but achieving this control is challenging. Here substrate control allows selectivity between these three positions in the enantioselective cyclisation of ethynyl benzoxazinanones and sulfamate-derived cyclic imines.