The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma

Abstract

Aim: We aimed to show the relationship between blood neutrophil to lymphocyte ratio that is systemic inflammatory marker and tumor size, tumor number, macro-vascular invasion at the time of diagnosis in patients with hepatocellular carcinoma.Methods: A total 48 patients diagnosed with hepatocellular carcinoma were included in our study. The patients were divided into two groups according to the median neutrophil to lymphocyte ratio.Results: A total of 48 patients (11 female, 37 male) were included in our study. The mean age of the patients were 67.18±9.51 years-old. The median neutrophil to lym-phocyte ratio was 3.17. There were significant association between neutrophil to lym-phocyte ratio > 3.17 and macrovascular invasion, the tumor number> 3, the tumor size> 5 cm, Child-Turcot-Pugh score, Model for End-stage Liver Disease- Sodium score, C-reactive protein and blood sodium level (p: 0.005, p: 0.009, p< 0.001, p: 0.003, p:0.008, p: 0.035 and p < 0.001, respectively). Multiple logistic lineer regres-sion analysis showed that NLR> 3.17 was an independent predictor of tumor size> 5 cm and hyponatremia in patients with hepatocellular carcinoma (p: 0.010, p: 0.012, respectively).Conclusions: The value of blood neutrophil to lymphocyte ratio at the time of diag-nosis in patients with hepatocellular carcinoma was a good predictor of tumor size and grade of disease.

Keywords

• nötrofil lenfosit oranı
• tümör boyutu
• hepatoselüler karsinoma
• neutrophil to lymphocyte ratio
• tumor size
• hepatocellular carcinoma