Nature Communications (Oct 2022)
Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration
- Tom W. Andrew,
- Lauren S. Koepke,
- Yuting Wang,
- Michael Lopez,
- Holly Steininger,
- Danielle Struck,
- Tatiana Boyko,
- Thomas H. Ambrosi,
- Xinming Tong,
- Yuxi Sun,
- Gunsagar S. Gulati,
- Matthew P. Murphy,
- Owen Marecic,
- Ruth Telvin,
- Katharina Schallmoser,
- Dirk Strunk,
- Jun Seita,
- Stuart B. Goodman,
- Fan Yang,
- Michael T. Longaker,
- George P. Yang,
- Charles K. F. Chan
Affiliations
- Tom W. Andrew
- Department of Surgery, Stanford University School of Medicine
- Lauren S. Koepke
- Department of Surgery, Stanford University School of Medicine
- Yuting Wang
- Department of Surgery, Stanford University School of Medicine
- Michael Lopez
- Department of Surgery, Stanford University School of Medicine
- Holly Steininger
- Department of Surgery, Stanford University School of Medicine
- Danielle Struck
- Department of Surgery, Stanford University School of Medicine
- Tatiana Boyko
- Department of Surgery, Stanford University School of Medicine
- Thomas H. Ambrosi
- Department of Surgery, Stanford University School of Medicine
- Xinming Tong
- Department of Bioengineering, Stanford University
- Yuxi Sun
- Department of Surgery, University of Alabama at Birmingham
- Gunsagar S. Gulati
- Department of Surgery, Stanford University School of Medicine
- Matthew P. Murphy
- Department of Surgery, Stanford University School of Medicine
- Owen Marecic
- Department of Surgery, Stanford University School of Medicine
- Ruth Telvin
- Division of Plastic and Reconstructive Surgery, Stanford Hospital and Clinics
- Katharina Schallmoser
- Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Department for Transfusion Medicine, Paracelsus Medical University of Salzburg
- Dirk Strunk
- Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Department for Transfusion Medicine, Paracelsus Medical University of Salzburg
- Jun Seita
- Center for Integrative Medical Sciences and Advanced Data Science Project, RIKEN
- Stuart B. Goodman
- Department of Orthopedic Surgery, Stanford University
- Fan Yang
- Department of Bioengineering, Stanford University
- Michael T. Longaker
- Department of Surgery, Stanford University School of Medicine
- George P. Yang
- Department of Surgery, University of Alabama at Birmingham
- Charles K. F. Chan
- Department of Surgery, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34063-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
How bone-related sexually dimorphic traits are regulated hasn’t been examined at the stem cell level. Here the authors show that skeletal stem cells (SSC), in female but not male mice, are directly controlled by estrogen signaling, which could be augmented to improve fracture repair.
