Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS

Wei-Lin Wan; Bo Tian; Yu-Jung Lin; Chiranjeevi Korupalli; Ming-Yen Lu; Qinghua Cui; Dehui Wan; Yen Chang; Hsing-Wen Sung

doi:10.1038/s41467-020-14413-x

Nature Communications (Jan 2020)

Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS

Wei-Lin Wan,
Bo Tian,
Yu-Jung Lin,
Chiranjeevi Korupalli,
Ming-Yen Lu,
Qinghua Cui,
Dehui Wan,
Yen Chang,
Hsing-Wen Sung

Affiliations

Wei-Lin Wan: Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University
Bo Tian: Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University
Yu-Jung Lin: Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University
Chiranjeevi Korupalli: Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University
Ming-Yen Lu: Department of Materials Science and Engineering, National Tsing Hua University
Qinghua Cui: Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University
Dehui Wan: Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University
Yen Chang: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University
Hsing-Wen Sung: Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University

DOI: https://doi.org/10.1038/s41467-020-14413-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Hydrogen can be used to reduce the concentration of reactive oxygen species (ROS), but its delivery to diseased tissues is challenging due to its low solubility. Here the authors develop a photosynthesis-inspired FRET nanocomplex to detect and scavenge local excess of ROS in the tissue using photocatalytic hydrogen production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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