Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

Samir Olatunji; Xiaoxiao Yu; Jonathan Bailey; Chia-Ying Huang; Marta Zapotoczna; Katherine Bowen; Maja Remškar; Rolf Müller; Eoin M. Scanlan; Joan A. Geoghegan; Vincent Olieric; Martin Caffrey

doi:10.1038/s41467-019-13724-y

Nature Communications (Jan 2020)

Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

Samir Olatunji,
Xiaoxiao Yu,
Jonathan Bailey,
Chia-Ying Huang,
Marta Zapotoczna,
Katherine Bowen,
Maja Remškar,
Rolf Müller,
Eoin M. Scanlan,
Joan A. Geoghegan,
Vincent Olieric,
Martin Caffrey

Affiliations

Samir Olatunji: Membrane Structural and Functional Biology Group, School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin
Xiaoxiao Yu: Membrane Structural and Functional Biology Group, School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin
Jonathan Bailey: Membrane Structural and Functional Biology Group, School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin
Chia-Ying Huang: Swiss Light Source, Paul Scherrer Institute
Marta Zapotoczna: Moyne Institute of Preventive Medicine, Department of Microbiology, School of Genetics and Microbiology, Trinity College Dublin
Katherine Bowen: School of Chemistry, Trinity College Dublin
Maja Remškar: Department Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmacy, Saarland University Campus E8 1
Rolf Müller: Department Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmacy, Saarland University Campus E8 1
Eoin M. Scanlan: School of Chemistry, Trinity College Dublin
Joan A. Geoghegan: Moyne Institute of Preventive Medicine, Department of Microbiology, School of Genetics and Microbiology, Trinity College Dublin
Vincent Olieric: Swiss Light Source, Paul Scherrer Institute
Martin Caffrey: Membrane Structural and Functional Biology Group, School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin

DOI: https://doi.org/10.1038/s41467-019-13724-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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The enzyme LspA from the human pathogen Staphylococcus aureus (MRSA) contributes to the integrity and function of the bacterial cell envelope. Here, authors provide crystal structures of LspA in complex with two natural antibiotics, which have profoundly different structures but inhibit LspA in an identical way.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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