Improvement of survival outcomes of cholangiocarcinoma by ultrasonography surveillance: Multicenter retrospective cohorts
Nittaya Chamadol,
Vallop Laopaiboon,
Apiwat Jareanrat,
Vasin Thanasukarn,
Tharatip Srisuk,
Vor Luvira,
Poowanai Sarkhampee,
Winai Ungpinitpong,
Phummarat Khamvijite,
Yutthapong Chumnanua,
Nipath Nethuwakul,
Passakorn Sodarat,
Samrit Thammarit,
Anchalee Techasen,
Jaruwan Thuanman,
Chaiwat Tawarungruang,
Bandit Thinkhamrop,
Prakasit Sa-Ngiamwibool,
Watcharin Loilome,
Piya Prajumwongs,
Attapol Titapun
Affiliations
Nittaya Chamadol
Departments of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Vallop Laopaiboon
Departments of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Apiwat Jareanrat
Departments of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Vasin Thanasukarn
Departments of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Tharatip Srisuk
Departments of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Vor Luvira
Departments of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Poowanai Sarkhampee
Departments of Surgery, Sunpasitthiprasong Hospital, Ubon Ratchathani Province, Thailand
Winai Ungpinitpong
Departments of Surgery, Surin Hospital, Surin Province, Thailand
Phummarat Khamvijite
Departments of Surgery, Surin Hospital, Surin Province, Thailand
Yutthapong Chumnanua
Departments of Surgery, Roi Et Hospital, Roi Et Province, Thailand
Nipath Nethuwakul
Departments of Surgery, Roi Et Hospital, Roi Et Province, Thailand
Passakorn Sodarat
Departments of Surgery, Roi Et Hospital, Roi Et Province, Thailand
Samrit Thammarit
Departments of Surgery, Udonthani Hospital, Udon Thani Province, Thailand
Anchalee Techasen
Departments of Clinical Microbiology, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Jaruwan Thuanman
Data Management and Statistical Analysis Center (DAMASAC), Faculty of Public Health, Khon Kaen University, Khon Kean, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Chaiwat Tawarungruang
Data Management and Statistical Analysis Center (DAMASAC), Faculty of Public Health, Khon Kaen University, Khon Kean, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Bandit Thinkhamrop
Data Management and Statistical Analysis Center (DAMASAC), Faculty of Public Health, Khon Kaen University, Khon Kean, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Prakasit Sa-Ngiamwibool
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Watcharin Loilome
Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Piya Prajumwongs
Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand
Attapol Titapun
Departments of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand; Corresponding author. Departments of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Background: Most cholangiocarcinoma (CCA) patients present with late stage of disease because of the difficulty to diagnosis at an early stage, resulting in poor survival of CCA patients. The Cholangiocarcinoma Screening and Care Program showed that ultrasound screening was an effective tool for detecting early stage CCA. This study aims to evaluate the survival outcome of patients diagnosed by ultrasound screening (US) compared to walk-in symptomatic patients. Methods: The retrospective clinical data and medical records for this study were accessed in June 30, 2021. 5-year survival rates (5-YSR) and median survival time (MST) of CCA were calculated using the Kaplan-Meier method. Multivariate analyses were performed for significant factors from univariate analyses. Results: A total of 711 histologically proven CCA cases were examined including ultrasound screening and walk-in groups. The screening group having 5-YSR was 53.9 %, and MST was of 67.2 months, while walk-in group, the 5-YSR was 21.9 % and MST was 15.6 months (p < 0.001). In addition, multivariate analyses revealed that screening program was an independent factor to predict a good outcome of CCA patients when compared with walk-in group (p = 0.014). Conclusion: US is an effective tool for detecting early stage CCA leading to improve clinical outcome of CCA patients. Practically, US should be considered as a first tool for screening CCA in risk populations.
