Nature Communications (Mar 2017)

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

  • Akira Yokoi,
  • Yusuke Yoshioka,
  • Yusuke Yamamoto,
  • Mitsuya Ishikawa,
  • Shun-ichi Ikeda,
  • Tomoyasu Kato,
  • Tohru Kiyono,
  • Fumitaka Takeshita,
  • Hiroaki Kajiyama,
  • Fumitaka Kikkawa,
  • Takahiro Ochiya

DOI
https://doi.org/10.1038/ncomms14470
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Ovarian cancer is particularly deadly because it is difficult to detect at the pre-metastatic stage; extracellular vesicles (EVs) on the other hand are involved in the pre-metastatic niche preparation. Here the authors show that EVs mediate ovarian cancer metastasis in the peritoneal area by targeting the mesothelium.