T315I – a gatekeeper point mutation and its impact on the prognosis of chronic myeloid leukemia

Abstract

BCR-ABL kinase domain mutations are an important cause of resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukaemia (CML) of which T315I is the most treatment-resilient. This study aimed to observe the frequency of T315I and its impact on disease prognosis in terms of progression and survival.

Keywords

• bcr-abl
• chronic myeloid leukaemia (cml)
• disease progression
• overall survival
• resistance
• t315i mutation