Nature Communications (Jan 2017)

Divergent prion strain evolution driven by PrPC expression level in transgenic mice

  • Annick Le Dur,
  • Thanh Lan Laï,
  • Marie-George Stinnakre,
  • Aude Laisné,
  • Nathalie Chenais,
  • Sabine Rakotobe,
  • Bruno Passet,
  • Fabienne Reine,
  • Solange Soulier,
  • Laetitia Herzog,
  • Gaëlle Tilly,
  • Human Rézaei,
  • Vincent Béringue,
  • Jean-Luc Vilotte,
  • Hubert Laude

DOI
https://doi.org/10.1038/ncomms14170
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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PrPC protein plays a key role in prion transmission across species. Here, the authors compare transmission of a representative scrapie isolate to transgenic mice expressing variable levels of the same Prnp allele as the donor sheep, and find divergent strain propagation regulated by PrPCgene dosage.