Jornal Brasileiro de Pneumologia (Jan 2024)

The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma

  • Mariana Isadora Ribeiro Vieira,
  • Mônica Versiani Nunes Pinheiro de Queiroz,
  • Maria Borges Rabelo de Santana,
  • Hatilla dos Santos Silva,
  • Almirane Oliveira,
  • Camila Alexandrina Viana Figueiredo,
  • Eduardo Martín Tarazona Santos,
  • Ryan dos Santos Costa,
  • Laura Maria de Lima Belizário Facury Lasmar

DOI
https://doi.org/10.36416/1806-3756/e20230092
Journal volume & issue
Vol. 49, no. 6

Abstract

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ABSTRACT Objective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma. Methods: This was a cross-sectional study, nested within a prospective cohort study of patients with severe asthma. Two outcomes were evaluated: asthma control and bronchodilator reversibility. We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024 and rs2275913 in the IL17A gene; and rs3024498 in the IL10 gene. For the association analyses, we performed logistic regression in three genetic models (allelic, additive, and dominant). Results: The rs3024498 C allele in the IL10 gene was associated with failure to achieve asthma control despite regular treatment (p = 0.02). However, the G allele of the IL17A rs3819024 polymorphism was associated with failure to respond to stimulation with a b2 agonist. The rs2275913 polymorphism of the IL17A gene showed no relationship with asthma control or bronchodilator reversibility. Conclusions: In pediatric patients with severe asthma, the IL10 polymorphism appears to be associated with failure to achieve clinical control, whereas the IL17A polymorphism appears to be associated with a worse bronchodilator response. Knowledge of the involvement of these polymorphisms opens future directions for pharmacogenetic studies and for the implementation of individualized therapeutic management of severe asthma in pediatric patients.

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