HIV/AIDS: Research and Palliative Care (Jul 2022)

Incidence and Predictors of Virological Failure Among Adult HIV/AIDS Patients on Second-Line Anti-Retroviral Therapy, in Selected Public Hospital of Addis Ababa, Ethiopia: Retrospective Follow-Up Study

  • Zakaria HF,
  • Raru TB,
  • Hassen FA,
  • Ayana GM,
  • Merga BT,
  • Debele GR,
  • Kiflemariam G,
  • Kebede SA,
  • Ayele TA

Journal volume & issue
Vol. Volume 14
pp. 319 – 329

Abstract

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Hamdi Fekredin Zakaria,1 Temam Beshir Raru,1 Fila Ahmed Hassen,2 Galana Mamo Ayana,1 Bedasa Taye Merga,2 Gebiso Roba Debele,3 Genet Kiflemariam,4 Sewnet Adem Kebede,5 Tadesse Awoke Ayele5 1Department of Epidemiology and Biostatistics, School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Public Health and Health Policy, School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 3Department of Public Health, College of Health Sciences, Metu University, Metu, Ethiopia; 4International Institute for Primary Health Care, Addis Ababa, Ethiopia; 5Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Temam Beshir Raru, Department of Epidemiology and Biostatistics, School of Public Health, College of Health and Medical Sciences, Haramaya University, P.O. Box: 235, Harar, Ethiopia, Email [email protected]: Virological suppression for persons living with HIV (PLHIV) on antiretroviral therapy (ART) reached 85% at the end of 2018, still falling short of the UNAIDS target of 95%. In Ethiopia, there were studies on treatment failure focusing on viral suppression and immunological failure of ART users, but none of them have addressed virological failure for second-line regimens.Objective: This study was aimed to estimate the incidence and predictors of virological failure among HIV patients who were switched to second-line ART at the selected public hospitals in Addis Ababa.Methods: An institutional-based retrospective follow-up study was conducted from September 2018 to January 2021 at public hospitals in Addis Ababa. The sample size was determined by using the Schoenfeld formula. Data entry were done by Epi Data version-4.6.0.0 and exported to R-software version-4.1.0 for analysis. Kaplan–Meier methods were used to compare the survival estimates. Cox proportional hazard model was used to identify predictors of virological failure and model adequacy was checked by using the Cox–Snell residuals plot.Results: Overall 44 (12.22%) HIV/AIDS patients developed virological failure with incidence density of 3.57/1000 Person-Month (PM) with 95% CI of [2.65– 4.79]. Age > 45 years (AHR=0.36, 95% CI: 0.12– 0.99), CD4 count < 100cell/mm3 (AHR=3.02, 95% CI: 1.17– 7.78), TB co-infection (AHR=2.48, 95% CI: 1.10– 6.33), ATV/r-based second-line regimen (AHR=0.27, 95% CI: 0.11– 0.70), and poor adherence at the start of second-line ART (AHR=6.18, 95% CI: 1.93– 19.76) were the significant predictors of virological failure.Conclusion: A high incidence of virological failure was noticed. The rate of virological failure was higher for patients who had poor ART adherence, small CD4count, and TB co-infection. Therefore, targeted HIV care interventions shall be provided to young ages and efforts stepped up to improve adherence to ART, which helps to increase immunity and suppress viral replication. In addition, prevention and early detection of TB co-infection are crucial to the patients.Keywords: incidence, second-line antiretroviral therapy, predictors, virological failure, HIV/AIDS

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