Nature Communications (Nov 2022)
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
- Kan Xie,
- Helmut Fuchs,
- Enzo Scifo,
- Dan Liu,
- Ahmad Aziz,
- Juan Antonio Aguilar-Pimentel,
- Oana Veronica Amarie,
- Lore Becker,
- Patricia da Silva-Buttkus,
- Julia Calzada-Wack,
- Yi-Li Cho,
- Yushuang Deng,
- A. Cole Edwards,
- Lillian Garrett,
- Christina Georgopoulou,
- Raffaele Gerlini,
- Sabine M. Hölter,
- Tanja Klein-Rodewald,
- Michael Kramer,
- Stefanie Leuchtenberger,
- Dimitra Lountzi,
- Phillip Mayer-Kuckuk,
- Lena L. Nover,
- Manuela A. Oestereicher,
- Clemens Overkott,
- Brandon L. Pearson,
- Birgit Rathkolb,
- Jan Rozman,
- Jenny Russ,
- Kristina Schaaf,
- Nadine Spielmann,
- Adrián Sanz-Moreno,
- Claudia Stoeger,
- Irina Treise,
- Daniele Bano,
- Dirk H. Busch,
- Jochen Graw,
- Martin Klingenspor,
- Thomas Klopstock,
- Beverly A. Mock,
- Paolo Salomoni,
- Carsten Schmidt-Weber,
- Marco Weiergräber,
- Eckhard Wolf,
- Wolfgang Wurst,
- Valérie Gailus-Durner,
- Monique M. B. Breteler,
- Martin Hrabě de Angelis,
- Dan Ehninger
Affiliations
- Kan Xie
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Helmut Fuchs
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Enzo Scifo
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Dan Liu
- Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
- Ahmad Aziz
- Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
- Juan Antonio Aguilar-Pimentel
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Oana Veronica Amarie
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Lore Becker
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Patricia da Silva-Buttkus
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Julia Calzada-Wack
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Yi-Li Cho
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Yushuang Deng
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- A. Cole Edwards
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Lillian Garrett
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Christina Georgopoulou
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Raffaele Gerlini
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Sabine M. Hölter
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Tanja Klein-Rodewald
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Michael Kramer
- GEMoaB GmbH
- Stefanie Leuchtenberger
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Dimitra Lountzi
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Phillip Mayer-Kuckuk
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Lena L. Nover
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Manuela A. Oestereicher
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Clemens Overkott
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Brandon L. Pearson
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Birgit Rathkolb
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Jan Rozman
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Jenny Russ
- Nuclear Function Lab, German Center for Neurodegenerative Diseases (DZNE)
- Kristina Schaaf
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- Nadine Spielmann
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Adrián Sanz-Moreno
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Claudia Stoeger
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Irina Treise
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Daniele Bano
- Aging and Neurodegeneration Lab, German Center for Neurodegenerative Diseases (DZNE)
- Dirk H. Busch
- Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München
- Jochen Graw
- Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Martin Klingenspor
- Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Technische Universität München
- Thomas Klopstock
- Friedrich-Baur-Institut, Department of Neurology, Ludwig-Maximilians-University Munich
- Beverly A. Mock
- Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH
- Paolo Salomoni
- Nuclear Function Lab, German Center for Neurodegenerative Diseases (DZNE)
- Carsten Schmidt-Weber
- Center of Allergy & Environment (ZAUM), Technische Universität München, and Helmholtz Zentrum München
- Marco Weiergräber
- Research Group Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices
- Eckhard Wolf
- Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich
- Wolfgang Wurst
- Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Valérie Gailus-Durner
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Monique M. B. Breteler
- Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
- Martin Hrabě de Angelis
- Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health
- Dan Ehninger
- Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
- DOI
- https://doi.org/10.1038/s41467-022-34515-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 29
Abstract
Lifespan can be affected by both physiological ageing and specific sets of pathologies associated with old age. Here the authors report a resource of large-scale cross-sectional phenotyping of aging male mice at different time points to analyse a large set of phenotypes and molecular markers, including during genetic and diet interventions affecting lifespan.
