A Rare Case of Complete-Immunotherapy-Responsive Metastatic Non-Small Cell Lung Cancer with Long Lasting Progression-Free Survival: A Case Report

Claudia De Intinis; Paolo Izzo; Massimo Codacci-Pisanelli; Luciano Izzo; Daniela Messineo; Simone Sibio; Monica Campagnol; Silvia Lai; Marcello Molle; Sara Izzo

doi:10.3390/curroncol31020053

Current Oncology (Jan 2024)

A Rare Case of Complete-Immunotherapy-Responsive Metastatic Non-Small Cell Lung Cancer with Long Lasting Progression-Free Survival: A Case Report

Claudia De Intinis,
Paolo Izzo,
Massimo Codacci-Pisanelli,
Luciano Izzo,
Daniela Messineo,
Simone Sibio,
Monica Campagnol,
Silvia Lai,
Marcello Molle,
Sara Izzo

Affiliations

Claudia De Intinis: Department of Surgery “Pietro Valdoni”, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Paolo Izzo: Department of Surgery “Pietro Valdoni”, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Massimo Codacci-Pisanelli: Department of Surgery “Pietro Valdoni”, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Luciano Izzo: Department of Surgery “Pietro Valdoni”, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Daniela Messineo: Department of Radiological Sciences, Oncology and Anatomo-Pathological Science, “Sapienza” University of Rome, Viale dell’Universitá 31/33, 00161 Rome, Italy
Simone Sibio: Department of Surgery “Pietro Valdoni”, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Monica Campagnol: Department of Surgery “Pietro Valdoni”, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Silvia Lai: Department of Translational and Precision Medicine, Nephrology Unit, “Sapienza” University of Rome, Viale dell’Universitá 31/33, 00161 Rome, Italy
Marcello Molle: Multidisciplinary Department of Medical-Surgical and Dental Specialties, Plastic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia 1, 80138 Naples, Italy
Sara Izzo: Multidisciplinary Department of Medical-Surgical and Dental Specialties, Plastic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia 1, 80138 Naples, Italy

DOI: https://doi.org/10.3390/curroncol31020053
Journal volume & issue: Vol. 31, no. 2
pp. 723 – 732

Abstract

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Background and introduction: Lung cancer is a prevalent and deadly disease globally. Non-small cell lung cancer (NSCLC) is the most common subtype, comprising 85% of cases. Case report: A 65-year-old male ex-smoker presented to our facility with a nocturnal cough. Various investigations revealed that he had metastatic NSCLC, for which he underwent chemotherapy with cisplatin and gemcitabine, followed by immunotherapy with Nivolumab. He achieved a complete response to the therapy and has remained free from recurrence for over 7 years since the initial diagnosis. Discussion and Conclusions: The treatment of metastatic NSCLC remains a significant therapeutic challenge, but the implementation of new therapeutic techniques has expanded the possibilities of achieving complete and durable eradication of the disease.

Published in Current Oncology

ISSN: 1198-0052 (Print); 1718-7729 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/curroncol

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