Nature Communications (Nov 2020)
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus
- Chan Hee Lee,
- Do Kyeong Song,
- Chae Beom Park,
- Jeewon Choi,
- Gil Myoung Kang,
- Sung Hoon Shin,
- Ijoo Kwon,
- Soyoung Park,
- Seongjun Kim,
- Ji Ye Kim,
- Hong Dugu,
- Jae Woo Park,
- Jong Han Choi,
- Se Hee Min,
- Jong-Woo Sohn,
- Min-Seon Kim
Affiliations
- Chan Hee Lee
- Asan Institute for Life Science, University of Ulsan College of Medicine
- Do Kyeong Song
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine
- Chae Beom Park
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center and University of Ulsan College of Medicine
- Jeewon Choi
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology
- Gil Myoung Kang
- Asan Institute for Life Science, University of Ulsan College of Medicine
- Sung Hoon Shin
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center and University of Ulsan College of Medicine
- Ijoo Kwon
- Asan Institute for Life Science, University of Ulsan College of Medicine
- Soyoung Park
- Developmental Neuroscience & Diabetes and Obesity Programs, Children’s Hospital Los Angeles, University of Southern California
- Seongjun Kim
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center and University of Ulsan College of Medicine
- Ji Ye Kim
- Asan Institute for Life Science, University of Ulsan College of Medicine
- Hong Dugu
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center and University of Ulsan College of Medicine
- Jae Woo Park
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center and University of Ulsan College of Medicine
- Jong Han Choi
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine
- Se Hee Min
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine
- Jong-Woo Sohn
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology
- Min-Seon Kim
- Asan Institute for Life Science, University of Ulsan College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19638-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Ciliary defects and obesity has been associated, but the underlying mechanism is unclear. Here, the authors show that inhibition of ciliogenesis in POMC neurons during development results in lysosomal protein degradation-dependent axonal disruption and adult obesity in mice.
