Revealing the human mucinome

Stacy A. Malaker; Nicholas M. Riley; D. Judy Shon; Kayvon Pedram; Venkatesh Krishnan; Oliver Dorigo; Carolyn R. Bertozzi

doi:10.1038/s41467-022-31062-4

Nature Communications (Jun 2022)

Revealing the human mucinome

Stacy A. Malaker,
Nicholas M. Riley,
D. Judy Shon,
Kayvon Pedram,
Venkatesh Krishnan,
Oliver Dorigo,
Carolyn R. Bertozzi

Affiliations

Stacy A. Malaker: Department of Chemistry and Stanford ChEM-H, Stanford University
Nicholas M. Riley: Department of Chemistry and Stanford ChEM-H, Stanford University
D. Judy Shon: Department of Chemistry and Stanford ChEM-H, Stanford University
Kayvon Pedram: Department of Chemistry and Stanford ChEM-H, Stanford University
Venkatesh Krishnan: Stanford Women’s Cancer Center, Division of Gynecologic Oncology, Stanford University
Oliver Dorigo: Stanford Women’s Cancer Center, Division of Gynecologic Oncology, Stanford University
Carolyn R. Bertozzi: Department of Chemistry and Stanford ChEM-H, Stanford University

DOI: https://doi.org/10.1038/s41467-022-31062-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

Mucin-domain glycoproteins are densely O-glycosylated proteins with unique secondary structure that imparts a large influence on cellular environments. Here, the authors develop a technique to selectively enrich and characterize mucin-domain glycoproteins from cell lysate and patient biofluids.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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