International Journal of Nanomedicine (May 2020)
In-situ Electrospinning for Intestinal Hemostasis
Abstract
Tongtong Zhou,1,* Yaozhong Wang,2,* Fengcai Lei,3 Jing Yu4 1Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao 266071, People’s Republic of China; 2Department of Oral and Maxillo-Facial Surgery, Qingdao Stomatological Hospital, Qingdao, People’s Republic of China; 3College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, People’s Republic of China; 4School of Physics and Electronics, Shandong Normal University, Jinan 250014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fengcai Lei; Jing Yu Email [email protected]; [email protected]: During routine surgery, rapid hemostasis, especially the rapid hemostasis of internal organs, is very important. The emergence of in-situ electrospinning technology has fundamentally solved this problem. It exhibits a high speed of hemostasis, and no bleeding occurs after surgery. Thus, it is of great significance. The use of sutures in some human organs, such as the intestines and bladder, is inadequate because fluid leakage occurs due to the presence of pinholes.Methods: Three types of large intestine wounds with an opening of about 1 cm were investigated. They were untreated, treated by needle and threaded, and treated by hand-held electrospinning, respectively.Results: The results show that hand-held electrospinning technique effectively prevented the exudation of fluids in the intestinal tract. The average diameter of the nanofibrous membrane was about 0.5 μm with hole of several micrometers. It can be elongated 90% without breakage. The hand-held electrospinning device could be used with nitrile gloves, preventing the risk of infection caused by exposed hands.Discussion: This work can provide a reference for future animal experiments and clinical experiments. However, safety should be investigated before application.Keywords: electrospinning, hemostasis, nanofibers
