eLife (Oct 2024)

Novel risk loci for COVID-19 hospitalization among admixed American populations

  • Silvia Diz-de Almeida,
  • Raquel Cruz,
  • Andre D Luchessi,
  • José M Lorenzo-Salazar,
  • Miguel López de Heredia,
  • Inés Quintela,
  • Rafaela González-Montelongo,
  • Vivian Nogueira Silbiger,
  • Marta Sevilla Porras,
  • Jair Antonio Tenorio Castaño,
  • Julian Nevado,
  • Jose María Aguado,
  • Carlos Aguilar,
  • Sergio Aguilera-Albesa,
  • Virginia Almadana,
  • Berta Almoguera,
  • Nuria Alvarez,
  • Álvaro Andreu-Bernabeu,
  • Eunate Arana-Arri,
  • Celso Arango,
  • María J Arranz,
  • Maria-Jesus Artiga,
  • Raúl C Baptista-Rosas,
  • María Barreda- Sánchez,
  • Moncef Belhassen-Garcia,
  • Joao F Bezerra,
  • Marcos AC Bezerra,
  • Lucía Boix-Palop,
  • María Brion,
  • Ramón Brugada,
  • Matilde Bustos,
  • Enrique J Calderón,
  • Cristina Carbonell,
  • Luis Castano,
  • Jose E Castelao,
  • Rosa Conde-Vicente,
  • M Lourdes Cordero-Lorenzana,
  • Jose L Cortes-Sanchez,
  • Marta Corton,
  • M Teresa Darnaude,
  • Alba De Martino-Rodríguez,
  • Victor del Campo-Pérez,
  • Aranzazu Diaz de Bustamante,
  • Elena Domínguez-Garrido,
  • Rocío Eirós,
  • María Carmen Fariñas,
  • María J Fernandez-Nestosa,
  • Uxía Fernández-Robelo,
  • Amanda Fernández-Rodríguez,
  • Tania Fernández-Villa,
  • Manuela Gago-Dominguez,
  • Belén Gil-Fournier,
  • Javier Gómez-Arrue,
  • Beatriz González Álvarez,
  • Fernan Gonzalez Bernaldo de Quirós,
  • Anna González-Neira,
  • Javier González-Peñas,
  • Juan F Gutiérrez-Bautista,
  • María José Herrero,
  • Antonio Herrero-Gonzalez,
  • María A Jimenez-Sousa,
  • María Claudia Lattig,
  • Anabel Liger Borja,
  • Rosario Lopez-Rodriguez,
  • Esther Mancebo,
  • Caridad Martín-López,
  • Vicente Martín,
  • Oscar Martinez-Nieto,
  • Iciar Martinez-Lopez,
  • Michel F Martinez-Resendez,
  • Angel Martinez-Perez,
  • Juliana F Mazzeu,
  • Eleuterio Merayo Macías,
  • Pablo Minguez,
  • Victor Moreno Cuerda,
  • Silviene F Oliveira,
  • Eva Ortega-Paino,
  • Mara Parellada,
  • Estela Paz-Artal,
  • Ney PC Santos,
  • Patricia Pérez-Matute,
  • Patricia Perez,
  • M Elena Pérez-Tomás,
  • Teresa Perucho,
  • Mellina Pinsach-Abuin,
  • Guillermo Pita,
  • Ericka N Pompa-Mera,
  • Gloria L Porras-Hurtado,
  • Aurora Pujol,
  • Soraya Ramiro León,
  • Salvador Resino,
  • Marianne R Fernandes,
  • Emilio Rodríguez-Ruiz,
  • Fernando Rodriguez-Artalejo,
  • José A Rodriguez-Garcia,
  • Francisco Ruiz-Cabello,
  • Javier Ruiz-Hornillos,
  • Pablo Ryan,
  • José Manuel Soria,
  • Juan Carlos Souto,
  • Eduardo Tamayo,
  • Alvaro Tamayo-Velasco,
  • Juan Carlos Taracido-Fernandez,
  • Alejandro Teper,
  • Lilian Torres-Tobar,
  • Miguel Urioste,
  • Juan Valencia-Ramos,
  • Zuleima Yáñez,
  • Ruth Zarate,
  • Itziar de Rojas,
  • Agustín Ruiz,
  • Pascual Sánchez,
  • Luis Miguel Real,
  • SCOURGE Cohort Group,
  • Encarna Guillen-Navarro,
  • Carmen Ayuso,
  • Esteban Parra,
  • José A Riancho,
  • Augusto Rojas-Martinez,
  • Carlos Flores,
  • Pablo Lapunzina,
  • Ángel Carracedo

DOI
https://doi.org/10.7554/eLife.93666
Journal volume & issue
Vol. 13

Abstract

Read online

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

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