Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives

Abstract

New imidazole ring derivatives comprising 1,3-oxazoline, Schiff's bases, thiadiazole, oxadiazole and 1,2,4-triazole moieties are reported. 3-Aminobiimidazol-4-one compounds 7a-c were synthesized by the reaction of compounds 6a-c with hydrazine hydrate. Biimidazole esters 9a-c were converted into biimidazole hydrazide esters 10a-c. Compounds 7a-c and 10a-c were converted into a variety of derivatives.

Keywords

• metronidazole
• biimidazole
• imidazole
• 1
• 3
• 4-oxadiazole
• 1
• 2
• 4-triazole
• 1
• 3
• 4-thiadiazole