Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling

Abstract

The use of FeCl3 resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO2, in under a minute.

Keywords

• homocoupling
• iron salts
• microreactor
• organolithiums