Namık Kemal Tıp Dergisi (Dec 2019)
Evaluating Acute Interstitial Nephritis Rates in Renal Biopsies (Single Center Study)
Abstract
Aim:We aimed to evaluate the prevalence and clinicopathological features of acute interstitial nephritis in patients undergoing renal biopsy.Materials and Methods:A total of 1048 native kidney biopsies performed between 2010 and 2018 in the Nephrology Clinic of Katip Celebi University Atatürk Training and Research Hospital were reviewed retrospectively. The records of 42 patients with histopathological diagnosis of acute interstitial nephritis were screened. Medical history, clinical, laboratory and pathological findings, all treatments and results of all patients with acute interstitial nephritis were recorded.Results:The prevalence of acute interstitial nephritis in all renal biopsies was found 4%. We found that the most common cause of acute interstitial nephritis was non-steroid anti-inflammatory drugs (40.5% in 17 patients). Thirty patients (71.4%) received steroid treatment, among them renal function improved in 17 patients (56%). There was no significant difference between the groups receiving end not receiving steroid therapy in terms of complete recovery of renal function (p>0.05). During admission, 12 patients (28.6%) required acute hemodialysis and all of these patients received steroid treatment. A total of eight patients (19.0%) remained in the chronic hemodialysis program. Overall eight patients (19%) died due to acute interstitial nephritis during the follow-up.Conclusion:The prevalence and the most common etiologic factors of acute interstitial nephritis were found similar to literature. In particular, non-steroidal anti-inflammatory drugs took the first place. Therefore, the history of the drug should be questioned well in all patients. Firstly, the underlying etiologic cause of acute interstitial nephritis should be corrected.
