Nature Communications (Oct 2019)
Sequence variants with large effects on cardiac electrophysiology and disease
- Kristjan Norland,
- Gardar Sveinbjornsson,
- Rosa B. Thorolfsdottir,
- Olafur B. Davidsson,
- Vinicius Tragante,
- Sridharan Rajamani,
- Anna Helgadottir,
- Solveig Gretarsdottir,
- Jessica van Setten,
- Folkert W. Asselbergs,
- Jon Th. Sverrisson,
- Sigurdur S. Stephensen,
- Gylfi Oskarsson,
- Emil L. Sigurdsson,
- Karl Andersen,
- Ragnar Danielsen,
- Gudmundur Thorgeirsson,
- Unnur Thorsteinsdottir,
- David O. Arnar,
- Patrick Sulem,
- Hilma Holm,
- Daniel F. Gudbjartsson,
- Kari Stefansson
Affiliations
- Kristjan Norland
- deCODE genetics/Amgen Inc.
- Gardar Sveinbjornsson
- deCODE genetics/Amgen Inc.
- Rosa B. Thorolfsdottir
- deCODE genetics/Amgen Inc.
- Olafur B. Davidsson
- deCODE genetics/Amgen Inc.
- Vinicius Tragante
- deCODE genetics/Amgen Inc.
- Sridharan Rajamani
- deCODE genetics/Amgen Inc.
- Anna Helgadottir
- deCODE genetics/Amgen Inc.
- Solveig Gretarsdottir
- deCODE genetics/Amgen Inc.
- Jessica van Setten
- Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University
- Folkert W. Asselbergs
- Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University
- Jon Th. Sverrisson
- Department of Internal Medicine, Akureyri Hospital
- Sigurdur S. Stephensen
- Department of Paediatric Cardiology, Children’s Hospital, Landspitali-The National University Hospital of Iceland
- Gylfi Oskarsson
- Department of Paediatric Cardiology, Children’s Hospital, Landspitali-The National University Hospital of Iceland
- Emil L. Sigurdsson
- Department of Family Medicine, University of Iceland
- Karl Andersen
- Division of Cardiology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland
- Ragnar Danielsen
- Division of Cardiology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland
- Gudmundur Thorgeirsson
- deCODE genetics/Amgen Inc.
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen Inc.
- David O. Arnar
- deCODE genetics/Amgen Inc.
- Patrick Sulem
- deCODE genetics/Amgen Inc.
- Hilma Holm
- deCODE genetics/Amgen Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen Inc.
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- DOI
- https://doi.org/10.1038/s41467-019-12682-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Aberrant morphology of the QRS complex in an electrocardiogram can be associated with cardiac morbidity and mortality. Here, the authors perform genome-wide association studies for ten measures of the QRS complex in 81,192 individuals and find 86 previously unreported loci that associate with at least one parameter.
