The effect of X-linked dosage compensation on complex trait variation

Julia Sidorenko; Irfahan Kassam; Kathryn E. Kemper; Jian Zeng; Luke R. Lloyd-Jones; Grant W. Montgomery; Greg Gibson; Andres Metspalu; Tonu Esko; Jian Yang; Allan F. McRae; Peter M. Visscher

doi:10.1038/s41467-019-10598-y

Nature Communications (Jul 2019)

The effect of X-linked dosage compensation on complex trait variation

Julia Sidorenko,
Irfahan Kassam,
Kathryn E. Kemper,
Jian Zeng,
Luke R. Lloyd-Jones,
Grant W. Montgomery,
Greg Gibson,
Andres Metspalu,
Tonu Esko,
Jian Yang,
Allan F. McRae,
Peter M. Visscher

Affiliations

Julia Sidorenko: Institute for Molecular Bioscience, The University of Queensland
Irfahan Kassam: Institute for Molecular Bioscience, The University of Queensland
Kathryn E. Kemper: Institute for Molecular Bioscience, The University of Queensland
Jian Zeng: Institute for Molecular Bioscience, The University of Queensland
Luke R. Lloyd-Jones: Institute for Molecular Bioscience, The University of Queensland
Grant W. Montgomery: Institute for Molecular Bioscience, The University of Queensland
Greg Gibson: School of Biology and Centre for Integrative Genomics, Georgia Institute of Technology
Andres Metspalu: Estonian Genome Centre, Institute of Genomics, University of Tartu
Tonu Esko: Estonian Genome Centre, Institute of Genomics, University of Tartu
Jian Yang: Institute for Molecular Bioscience, The University of Queensland
Allan F. McRae: Institute for Molecular Bioscience, The University of Queensland
Peter M. Visscher: Institute for Molecular Bioscience, The University of Queensland

DOI: https://doi.org/10.1038/s41467-019-10598-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Dosage compensation (DC) on the X chromosome has predictable effects on genetic and phenotypic trait variance. Here, the authors use information for 20 quantitative traits in the UK Biobank and across-tissue gene expression to compare X-linked heritability and the effects of trait-associated SNPs between the sexes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal