Nature Communications (Aug 2016)
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
Abstract
The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.