Nature Communications (Jun 2018)
Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1
Abstract
hnRNP A1 is an auxiliary factor that promotes the Microprocessor-mediated processing of pri-mir-18a, of the oncomiR-1 cluster. Here the authors employ an integrative structural biology approach and provide insights into the molecular mechanism of how hnRNP A1 facilitates pri-mir-18a biogenesis.