Nature Communications (Jun 2018)

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1

  • Hamed Kooshapur,
  • Nila Roy Choudhury,
  • Bernd Simon,
  • Max Mühlbauer,
  • Alexander Jussupow,
  • Noemi Fernandez,
  • Alisha N. Jones,
  • Andre Dallmann,
  • Frank Gabel,
  • Carlo Camilloni,
  • Gracjan Michlewski,
  • Javier F. Caceres,
  • Michael Sattler

DOI
https://doi.org/10.1038/s41467-018-04871-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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hnRNP A1 is an auxiliary factor that promotes the Microprocessor-mediated processing of pri-mir-18a, of the oncomiR-1 cluster. Here the authors employ an integrative structural biology approach and provide insights into the molecular mechanism of how hnRNP A1 facilitates pri-mir-18a biogenesis.