Nature Communications (Oct 2018)
PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex
- Stephanie Link,
- Ramona M. M. Spitzer,
- Maryam Sana,
- Mario Torrado,
- Moritz C. Völker-Albert,
- Eva C. Keilhauer,
- Thomas Burgold,
- Sebastian Pünzeler,
- Jason K. K. Low,
- Ida Lindström,
- Andrea Nist,
- Catherine Regnard,
- Thorsten Stiewe,
- Brian Hendrich,
- Axel Imhof,
- Matthias Mann,
- Joel P. Mackay,
- Marek Bartkuhn,
- Sandra B. Hake
Affiliations
- Stephanie Link
- Department of Molecular Biology, BioMedical Center (BMC), Ludwig-Maximilians-University Munich
- Ramona M. M. Spitzer
- Department of Molecular Biology, BioMedical Center (BMC), Ludwig-Maximilians-University Munich
- Maryam Sana
- School of Life and Environmental Sciences, University of Sydney
- Mario Torrado
- School of Life and Environmental Sciences, University of Sydney
- Moritz C. Völker-Albert
- Department of Molecular Biology, BioMedical Center (BMC), Ludwig-Maximilians-University Munich
- Eva C. Keilhauer
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Thomas Burgold
- Wellcome Trust – MRC Stem Cell Institute and Department of Biochemistry, University of Cambridge
- Sebastian Pünzeler
- Department of Molecular Biology, BioMedical Center (BMC), Ludwig-Maximilians-University Munich
- Jason K. K. Low
- School of Life and Environmental Sciences, University of Sydney
- Ida Lindström
- School of Life and Environmental Sciences, University of Sydney
- Andrea Nist
- Genomics Core Facility, Philipps-University Marburg
- Catherine Regnard
- Department of Molecular Biology, BioMedical Center (BMC), Ludwig-Maximilians-University Munich
- Thorsten Stiewe
- Genomics Core Facility, Philipps-University Marburg
- Brian Hendrich
- Wellcome Trust – MRC Stem Cell Institute and Department of Biochemistry, University of Cambridge
- Axel Imhof
- Department of Molecular Biology, BioMedical Center (BMC), Ludwig-Maximilians-University Munich
- Matthias Mann
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Joel P. Mackay
- School of Life and Environmental Sciences, University of Sydney
- Marek Bartkuhn
- Institute for Genetics, Justus-Liebig University Giessen
- Sandra B. Hake
- Institute for Genetics, Justus-Liebig University Giessen
- DOI
- https://doi.org/10.1038/s41467-018-06665-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
PWWP2A is a chromatin-binding transcriptional regulator that mediates mitosis-progression. Here, the authors provide evidence that PWWP2A directly interacts with H2A.Z nucleosomes, DNA and H3K36me3, binds to an MTA1-specific subcomplex of the NuRD complex (M1HR) and promotes changes to histone acetylation.
