Photodynamic therapy in the prevention of HPV-associated cervical cancer recurrence

Abstract

Objective. To develop methodological approaches to relapse prevention of HPV-associated cervical cancer. Materials and methods. 40 patients with PDT performed in age from 22 to 46 years (median 33 years) with primary cervical cancer after surgical treatment of organ volume - high conical cervicectomy: carcinoma in situ (n=18) and cervical cancer 1A1st. (n=22). Identification and differentiation of HPV DNA polymerase made chain reaction. Alasens dose (20% ointment) was 0,1 mg/cm2, Exposure time 6 hours light source - diode laser LFT-630-01-BIOSPEC. Results. Complete eradication of HPV DNA after PDT cervical stump was achieved in 38 (95%) of the women in the other two - after the 2nd PDT. Resistant antiviral effect during the whole observation period is preserved in 39 (97,5%) women. Findings. Photodynamic therapy can be recommended with the aim of antiviral treatment in the second stage after amputation knife, laser, electro-and radio-wave cone excision of the cervix, as well as alternative and radiokoagulyatsii diathermy, cryosurgery, laser vaporization method of treatment of cervical PVI. Conclusion. These data antiviral efficacy of PDT are of great interest in the light of proven etiologic role of HPV in cervical cancer development.

Keywords

• photodynamic therapy
• cervical cancer
• cervical intraepithelial neoplasia
• human papillomavirus
• polymerase chain reaction
• 5-aminolevulinic acid
• protoporphyrin ix