Comparative study on the effect of cerium nano composite on juvenile hormones in adult and aged rats

Abstract

The acquisition of new nanomaterials with unique properties for biomedical application is an essential requirement and many nanoparticles are being studied to test their possible application in therapy. The present study aimed to evaluate the effect of nano-cerium/hydroxyapatite (nCe/HAp) as a regenerative agent for the juvenile hormones and the improvement of dyslipidemia in adult and aged rats. This study included two main groups of albino male rats (adult and aged), each of sixteen rats. Each group was divided equally into two subgroups, control and treated. Treated rats were injected intravenously with 75 mg/kg b. w. nCe/HAp weekly for four weeks. At the end of the experiment, the blood samples were collected between 12:00 and 1:00 (mid-dark) for biochemical analysis. The measurements of dehydroepianrsterone, dehydroepianrsterone sulphate, melatonin, and testosterone hormones were performed as well as lipid profile was analyzed. The obtained results revealed that nCe/HAp has a pronounced positive effect on juvenile hormones value and lipid profile status in adults more than in aged rats. Based on the experimental results, it can be established that nCe/HAp has a potential effect on improving the level of juvenile hormones in adult and aged rats. Therefore, it may candidate nCe/HAp composite as a regenerative drug in the event of hormonal imbalance resulting from dysfunction or aging in the future.

Keywords

• Nano-cerium
• Nano-hydroxyapatite
• Juvenile hormones
• Lipid profile
• Experimental rats