ALK-positive histiocytosis involving the cavernous sinus: A deceptive radiologic mimic of meningioma

Mohammadreza Alizadeh, MD; Aishwarya Ravindran, MD; Rati Chkheidze, MD; Gaurav Goyal, MD; Mahdie Hosseini, MD; Parnian Shobeiri, MD; Arezoo Shafieioun, MD; Mohammad Khalafi, MD; Ramin Shahidi; Houman Sotoudeh, MD; Aparna Singhal, MD

Radiology Case Reports (Jun 2023)

ALK-positive histiocytosis involving the cavernous sinus: A deceptive radiologic mimic of meningioma

Mohammadreza Alizadeh, MD,
Aishwarya Ravindran, MD,
Rati Chkheidze, MD,
Gaurav Goyal, MD,
Mahdie Hosseini, MD,
Parnian Shobeiri, MD,
Arezoo Shafieioun, MD,
Mohammad Khalafi, MD,
Ramin Shahidi,
Houman Sotoudeh, MD,
Aparna Singhal, MD

Affiliations

Mohammadreza Alizadeh, MD: Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
Aishwarya Ravindran, MD: Department of Clinical Pathology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA
Rati Chkheidze, MD: Department of Neuropathology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA
Gaurav Goyal, MD: Department of Medicine- Hematology and Oncology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA
Mahdie Hosseini, MD: Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
Parnian Shobeiri, MD: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Arezoo Shafieioun, MD: Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammad Khalafi, MD: Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran
Ramin Shahidi: School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Houman Sotoudeh, MD: Department of Radiology and Neurology, University of Alabama at Birmingham (UAB), 619 19th St S, Birmingham, AL 35294, USA; Corresponding author.
Aparna Singhal, MD: Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA

Journal volume & issue: Vol. 18, no. 6
pp. 2259 – 2263

Abstract

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Anaplastic lymphoma kinase (ALK)-positive histiocytosis is an uncommon condition, recently considered a separate condition from other histiocytosis by WHO 5th edition. It can involve intracranial structures. This manuscript describes a case of ALK-positive histiocytosis of the cavernous sinus, focusing on the radiologic and pathologic presentation of the entity. Our case had MRI manifestations mimicking meningioma, metastasis, and Langerhans histiocytosis. On CT imaging, benign osseous remodeling of the cavernous sinus was detected, which can be helpful in differentiating it from more common meningioma.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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