ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs

Paulus Mrass; Sreenivasa Rao Oruganti; G. Matthew Fricke; Justyna Tafoya; Janie R. Byrum; Lihua Yang; Samantha L. Hamilton; Mark J. Miller; Melanie E. Moses; Judy L. Cannon

doi:10.1038/s41467-017-01032-2

Nature Communications (Oct 2017)

ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs

Paulus Mrass,
Sreenivasa Rao Oruganti,
G. Matthew Fricke,
Justyna Tafoya,
Janie R. Byrum,
Lihua Yang,
Samantha L. Hamilton,
Mark J. Miller,
Melanie E. Moses,
Judy L. Cannon

Affiliations

Paulus Mrass: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine
Sreenivasa Rao Oruganti: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine
G. Matthew Fricke: Department of Computer Science, University of New Mexico
Justyna Tafoya: Department of Computer Science, University of New Mexico
Janie R. Byrum: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine
Lihua Yang: Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine
Samantha L. Hamilton: Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine
Mark J. Miller: Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine
Melanie E. Moses: Department of Computer Science, University of New Mexico
Judy L. Cannon: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine

DOI: https://doi.org/10.1038/s41467-017-01032-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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ROCK is associated with T cell movement in lymph nodes. Here the authors use an LPS lung damage model and two-photon imaging to show that CD8+ T cells in lung tissue engage in ROCK-dependent fast linear migration alternating with bursts of slower confined migration that together optimize contact with target cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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