Intracellular sodium elevation reprograms cardiac metabolism

Dunja Aksentijević; Anja Karlstaedt; Marina V. Basalay; Brett A. O’Brien; David Sanchez-Tatay; Seda Eminaga; Alpesh Thakker; Daniel A. Tennant; William Fuller; Thomas R. Eykyn; Heinrich Taegtmeyer; Michael J. Shattock

doi:10.1038/s41467-020-18160-x

Nature Communications (Aug 2020)

Intracellular sodium elevation reprograms cardiac metabolism

Dunja Aksentijević,
Anja Karlstaedt,
Marina V. Basalay,
Brett A. O’Brien,
David Sanchez-Tatay,
Seda Eminaga,
Alpesh Thakker,
Daniel A. Tennant,
William Fuller,
Thomas R. Eykyn,
Heinrich Taegtmeyer,
Michael J. Shattock

Affiliations

Dunja Aksentijević: School of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King’s College London, The Rayne Institute, St Thomas’ Hospital
Anja Karlstaedt: Department of Internal Medicine, Division of Cardiology, McGovern Medical School The University of Texas Health Science Center at Houston
Marina V. Basalay: School of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King’s College London, The Rayne Institute, St Thomas’ Hospital
Brett A. O’Brien: School of Biomedical Engineering and Imaging Sciences, King’s College London, St Thomas’ Hospital
David Sanchez-Tatay: School of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King’s College London, The Rayne Institute, St Thomas’ Hospital
Seda Eminaga: School of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King’s College London, The Rayne Institute, St Thomas’ Hospital
Alpesh Thakker: Institute of Metabolism and Systems Research, College of Medical and Dental Sciences University of Birmingham
Daniel A. Tennant: Institute of Metabolism and Systems Research, College of Medical and Dental Sciences University of Birmingham
William Fuller: Institute of Cardiovascular and Medical Sciences, University of Glasgow
Thomas R. Eykyn: School of Biomedical Engineering and Imaging Sciences, King’s College London, St Thomas’ Hospital
Heinrich Taegtmeyer: Department of Internal Medicine, Division of Cardiology, McGovern Medical School The University of Texas Health Science Center at Houston
Michael J. Shattock: School of Cardiovascular and Medical Sciences, British Heart Foundation Centre of Research Excellence, King’s College London, The Rayne Institute, St Thomas’ Hospital

DOI: https://doi.org/10.1038/s41467-020-18160-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mitochondrial Na/Ca exchange.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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