Nature Communications (Mar 2016)
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
- Yasuaki Kabe,
- Takanori Nakane,
- Ikko Koike,
- Tatsuya Yamamoto,
- Yuki Sugiura,
- Erisa Harada,
- Kenji Sugase,
- Tatsuro Shimamura,
- Mitsuyo Ohmura,
- Kazumi Muraoka,
- Ayumi Yamamoto,
- Takeshi Uchida,
- So Iwata,
- Yuki Yamaguchi,
- Elena Krayukhina,
- Masanori Noda,
- Hiroshi Handa,
- Koichiro Ishimori,
- Susumu Uchiyama,
- Takuya Kobayashi,
- Makoto Suematsu
Affiliations
- Yasuaki Kabe
- Department of Biochemistry, Keio University School of Medicine, and Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST)
- Takanori Nakane
- Department of Medical Chemistry and Cell Biology, Graduate School of Medicine, Kyoto University
- Ikko Koike
- Department of Biochemistry, Keio University School of Medicine, and Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST)
- Tatsuya Yamamoto
- Bioorganic Research Institute, Suntory Foundation for Life Sciences
- Yuki Sugiura
- Department of Biochemistry, Keio University School of Medicine, and Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST)
- Erisa Harada
- Bioorganic Research Institute, Suntory Foundation for Life Sciences
- Kenji Sugase
- Bioorganic Research Institute, Suntory Foundation for Life Sciences
- Tatsuro Shimamura
- Department of Medical Chemistry and Cell Biology, Graduate School of Medicine, Kyoto University
- Mitsuyo Ohmura
- Department of Biochemistry, Keio University School of Medicine, and Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST)
- Kazumi Muraoka
- Department of Biochemistry, Keio University School of Medicine, and Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST)
- Ayumi Yamamoto
- Department of Chemistry, Faculty of Science, Hokkaido University
- Takeshi Uchida
- Department of Chemistry, Faculty of Science, Hokkaido University
- So Iwata
- Department of Medical Chemistry and Cell Biology, Graduate School of Medicine, Kyoto University
- Yuki Yamaguchi
- Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
- Elena Krayukhina
- Department of Biotechnology, Graduate School of Engineering, Osaka University
- Masanori Noda
- Department of Biotechnology, Graduate School of Engineering, Osaka University
- Hiroshi Handa
- Department of Nanoparticle Translational Research, Tokyo Medical University
- Koichiro Ishimori
- Department of Chemistry, Faculty of Science, Hokkaido University
- Susumu Uchiyama
- Department of Biotechnology, Graduate School of Engineering, Osaka University
- Takuya Kobayashi
- Department of Medical Chemistry and Cell Biology, Graduate School of Medicine, Kyoto University
- Makoto Suematsu
- Department of Biochemistry, Keio University School of Medicine, JST, Exploratory Research for Advanced Technology (ERATO), Suematsu Gas Biology Project
- DOI
- https://doi.org/10.1038/ncomms11030
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
PGRMC1 binds to EGFR and cytochromes P450, and is known to be involved in cancer proliferation and in drug resistance. Here, the authors determine the structure of the cytosolic domain of PGRMC1, which forms a dimer via haem–haem stacking, and propose how this interaction could be involved in its function.
